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Journal of the American Academy of Dermatology
Volume 71, n° 1
pages 177-184 (juillet 2014)
Doi : 10.1016/j.jaad.2014.01.891
accepted : 31 January 2014

The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products

Matthew H. Meckfessel, PhD , Staci Brandt, PA-C, MSMR, MBA
 Galderma Laboratories LP, Fort Worth, Texas 

Reprint requests: Matthew H. Meckfessel, PhD, Galderma Laboratories LP, 14501 N Freeway, Fort Worth, TX 76177.

Ceramides (CERs) are epidermal lipids that are important for skin barrier function. Much research has been devoted to identifying the numerous CERs found in human skin and their function. Alterations in CER content are associated with a number of skin diseases such as atopic dermatitis. Newer formulations of skin-care products have incorporated CERs into their formulations with the goal of exogenously applying CERs to help skin barrier function. CERs are a complex class of molecules and because of their growing ubiquity in skin-care products, a clear understanding of their role in skin and use in skin-care products is essential for clinicians treating patients with skin diseases. This review provides an overview of the structure, function, and importance of skin CERs in diseased skin and how CERs are being used in skin-care products to improve or restore skin barrier function.

The full text of this article is available in PDF format.

Key words : ceramide, epidermal repair, skin barrier, skin care, skin disease

Abbreviations used : CER, CERSyn, FLG , TEWL

 Funded by Galderma Laboratories LP.
 Disclosure: Dr Meckfessel and Ms Brandt are employees of Galderma Laboratories LP.

© 2014  American Academy of Dermatology, Inc.@@#104156@@