A case of dual rhino-maxillary orbital infection caused by Rhizopus oryzae and Alternaria spp. is described in a child suffering from Hepatitis A. Direct microscopy of the biopsied tissue revealed the presence of hyphae of a Zygomycete and dark fungi. The tissue in culture yielded Rhizopus oryzae and Alternaria spp. The two pathogens were never seen together in the infected tissues. Histologic sections revealed inflammatory reaction, abscesses, blood vessels invasion, thrombosis and necrosis due to R. oryzae . Alternaria spp. appeared to cause non-invasive, localized infection. In vitro sensitivity test revealed ketoconazole to be active against both the pathogens. The patient had a smooth recovery when treated with oral ketoconazole after surgical intervention. The zygomycosis should be considered as a rare complication in Hepatitis A patients.