Irreversible electroporation for locally advanced pancreatic cancer - 05/12/16

Doi : 10.1016/j.diii.2016.10.001

J.-P. Tasu ^a,^⁎ , G. Vesselle ^a, G. Herpe ^a, J.-P. Richer ^b,^c, S. Boucecbi ^a, S. Vélasco ^a, M. Carretier ^c, B. Debeane ^d, D. Tougeron ^e
^a Department of Imaging, University Hospital of Poitiers, rue de la Milétrie, 86000 Poitiers, France
^b Laboratory of Simulations and Anatomy Department, University of Poitiers, rue de la Milétrie, 86000 Poitiers, France
^c Abdominal Surgery Department, University of Poitiers, rue de la Milétrie, 86000 Poitiers, France
^d Anaesthesiology Department, University Hospital of Poitiers, rue de la Milétrie, 86000 Poitiers, France
^e Abdominal Oncology Department, University Hospital of Poitiers, rue de la Milétrie, 86000 Poitiers, France

^⁎Corresponding author at: Département d’imagerie diagnostique, fonctionnelle et thérapeutique, CHU de Poitiers, rue de la Milétrie, 86000 Poitiers France.

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Abstract

Pancreatic adenocarcinoma is one of the solid cancers associated with the poorest prognosis; the only curative treatment remains surgical resection but in most cases, this treatment is not possible because of distant metastasis or local extension. Irreversible electroporation is a new tumor ablation technique, which provides cellular apoptosis without any thermal coagulation effect. This technique helps preserve the ducts, vessels or nerves located in the treatment area. This article reviews the current knowledge regarding the use of electroporation for the treatment of pancreatic adenocarcinoma.

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Keywords : Irreversible electroporation, Pancreas, Pancreatic adenocarcinoma, Cancer, Interventional radiology