Diagnostic value of 18F-FDG-PET/CT for the follow-up and restaging of soft tissue sarcomas in adults - 15/11/17
, O. Abdelaziz, S. Emad-Eldin
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Abstract |
Purpose |
The purpose of this study was to evaluate the clinical utility of 2-[18F] fluoro-2-deoxy-D-glucose (18FDG) positron emission tomography (PET)/computed tomography (CT) (18F-FDG-PET/CT) in the follow-up of adult patients with soft tissue sarcomas.
Materials and methods |
We prospectively evaluated 37 consecutive patients with known soft tissue sarcoma with 18F-FDG-PET/CT examination for suspected recurrence of disease. They were 21 men and 16 women with a mean age of 49.6±10.6 (SD) years (range, 34–75years). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of 18F-FDG-PET/CT examination were calculated on a per patient basis.
Results |
18F-FDG-PET/CT showed an overall diagnostic accuracy of 91.8%, sensitivity of 90% and a specificity of 100%. The positive predictive value and negative predictive value were 100 and 70%, respectively. The 18F-FDG-PET/CT interpretations were correct in 34/37 patients (91.8%). Incorrect interpretations occurred in three patients (8.1%). Reasons for false negative findings were low 18F-FDG uptake of local recurrence in one patient and low 18F-FDG uptake of subcentimetric inguinal lymph node metastases.
Conclusion |
18F-FDG-PET/CT has a high diagnostic value in the follow-up of patients with soft tissue sarcoma.
El texto completo de este artículo está disponible en PDF.Keywords : 18F-FDG-PET/CT, Soft tissue sarcomas, Accuracy study, Recurrent disease
Esquema
Vol 98 - N° 10
P. 693-698 - octobre 2017 Regresar al número
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