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Longitudinal study of a NoGo-P3 event-related potential component following mild traumatic brain injury in adults - 09/01/18

Doi : 10.1016/j.rehab.2017.07.246 
Gian Candrian a, , Andreas Müller a, Patrizia Dall’Acqua b, c, Kyveli Kompatsiari a, Gian-Marco Baschera a, Ladislav Mica d, Hans-Peter Simmen d, Richard Glaab e, Javier Fandino f, Markus Schwendinger g, Christoph Meier h, Erika Jasmin Ulbrich i, Sönke Johannes b
a Brain and Trauma Foundation Grisons, Poststrasse 22, CH-7000 Chur, Switzerland 
b Bellikon Rehabilitation Clinic, CH-5454 Bellikon, Switzerland 
c Division Neuropsychology, Department of Psychology, University of Zurich, CH-8050 Zurich, Switzerland 
d Division of Trauma Surgery, University Hospital Zurich, CH-8091 Zurich, Switzerland 
e Department of Traumatology, Cantonal Hospital Aarau, CH-5001 Aarau, Switzerland 
f Department of Neurosurgery, Cantonal Hospital Aarau, CH-5001 Aarau, Switzerland 
g Interdisciplinary Emergency Centre, Baden Cantonal Hospital, CH-5404 Baden, Switzerland 
h Department of Surgery, Waid City Hospital, CH-8037 Zurich, Switzerland 
i Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, CH-8091 Zurich, Switzerland 

Corresponding author. Brain and Trauma Foundation Grisons, Poststrasse 22, CH-7000 Chur, Switzerland.

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Abstract

Background

Event-related potentials have repeatedly revealed electrophysiological markers of cognitive dysfunction associated with Mild Traumatic Brain Injury (MTBI) and may represent a sensitive tool to guide cognitive rehabilitative interventions. We previously found patients with symptomatic MTBI characterized by smaller P300 (or P3) wave amplitudes in a NoGo-P3 subcomponent in the acute phase of the injury. The goal of this longitudinal study was to investigate whether this early NoGo-P3 subcomponent differs over time in symptomatic MTBI patients and healthy controls.

Methods

We included adults with a diagnosis of MTBI and individually matched healthy controls tested at 1 week, 3 months, and 1 year after the MTBI. Symptoms were assessed by the Rivermead Post-Concussion Symptoms Questionnaire. NoGo-P3 was collected by using a cued Go/NoGo task and the relevant subcomponent was extracted by independent component analysis.

Results

Among 53 adults with a diagnosis of MTBI and 53 controls, we included 35 with symptomatic MTBI and 35 matched healthy controls (18 females each group; mean age 34.06±13.15 and 34.26±12.98 years). Amplitudes for the early NoGo-P3 subcomponent were lower for symptomatic MTBI patients than controls (P<0.05) at 1 week post-injury. Furthermore, mixed ANOVA revealed a significant time by group interaction (P<0.05), so the effect of time differed for symptomatic MTBI patients and healthy controls. The amplitudes for MTBI patients normalized from 1 week to 3 months post-injury and were comparable to those of controls from 3 months to 1 year post-injury. However, amplitudes for 3 MTBI patients with particularly severe complaints 1 year post-injury did not normalize and were lower than those for the remaining MTBI sample (P<0.05).

Conclusions

Selected event-related potentials can be used as a sensitive and objective tool to illustrate the cognitive consequences of and recovery after MTBI.

El texto completo de este artículo está disponible en PDF.

Keywords : Mild traumatic brain injury, Event-related potentials, Independent component analysis, Longitudinal


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Vol 61 - N° 1

P. 18-26 - janvier 2018 Regresar al número
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