Omentin-1 protects renal function of mice with type 2 diabetic nephropathy via regulating miR-27a-Nrf2/Keap1 axis - 20/09/18
, Ruimin Guo a, Dongxiang Zhong a, Runxi Xu a, Meng Song aBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Highlights |
• | Omentin-1 was identified to protect renal function of type 2 DN mice. |
• | Omentin-1 could relieve the inflammatory response and suppress oxidative stress. |
• | Omentin-1 regulates Nrf2/Keap1 pathway by down-regulating miR-27a. |
Abstract |
Omentin-1, a novel identified adipokine, always significantly decreases in patients with metabolic syndrome. However, the functional roles of omentin-1 in diabetic nephropathy (DN) remains largely unknown. In the present study, we found that omentin-1 treatment could improve renal function of type 2 diabetic db/db mice. ELISA assay and immunohistochemistry staining showed that omentin-1 reduced the productions of proinflammatory cytokines (IFN-γ, TNF-α, MCP-1 and IL-8), and improved oxidative stress level (CAT, MDA and SOD) in the kidney tissue, indicating omentin-1 could relieved the inflammatory response and suppressed oxidative stress. Mechanistic analysis demonstrated that omentin-1 down-regulated miR-27a expression, and subsequently inhibited oxidative stress and inflammation. Luciferase reporter assay and western blot further revealed that miR-27a directly targeted the 3′ untranslated region (UTR) of nuclear factor erythroid 2-like 2 (Nrf2) and reduced its expression in type 2 DN. Taken together, these findings provide a new function of omentin-1 in renal protection and also delineate multiple potential targets for therapeutic intervention for type 2 DN.
El texto completo de este artículo está disponible en PDF.Keywords : Omentin-1, Diabetic nephropathy, miR-27a, Nuclear factor erythroid 2-like 2, Oxidative stress
Esquema
Vol 107
P. 440-446 - novembre 2018 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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