Postmenopausal osteoporosis and breast cancer: The biochemical links and beneficial effects of functional foods - 20/09/18
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Highlights |
• | Breast cancer has been classified among the major causes of death in women. |
• | Pre and post-menopausal women are the major targets when it comes to breast cancer and osteoporosis. |
• | This may not be unconnected to the fact that, there may be existent biochemical links between the two mayhems. |
• | These might rally round between the cellular and molecular connectivity based on the actions and inactions of RANKL, estrogen and free radicals-induced oxidative stress. |
• | The potentials of functional foods in preventing, managing and possibly treating breast cancer and postmenopausal osteoporosis cannot be overemphasised. |
Abstract |
Breast cancer as a multifactorial disease has been classified among the major causes of morbidity and mortality in women across the world, with a higher prevalence among post-menopausal women. Osteoporosis, a condition characterized by altered bone mineralization is also commonly found among post-menopausal women. Consequently, post-menopausal women are at risk of morbidity and mortality associated with breast cancer and postmenopausal osteoporosis. This may not be unconnected to the fact that, there may be existent biochemical links between the two mayhems, which might rally round between the cellular and molecular connectivity based on the actions and inactions of RANKL, estrogen, free radicals-induced oxidative stress and metabolic implications of age related obesity among others. Cells and tissues including breast and bone are more prone to oxidative stress with age, and oxidative stress could alter the activity of key proteins and pathways required for protection against breast cancer and osteoporosis. As a result, the potentials of antioxidant rich functional foods in preventing, managing and possibly treating breast cancer and postmenopausal osteoporosis cannot be overemphasised. This review mainly uses ISI, SCOPUS and PubMed indexed journals and books containing various experimental reports vacillating from humans, animals and in vitro studies in relation to breast cancer and postmenopausal osteoporosis, biochemical links and possible beneficial effects of functional foods. One distinct feature of the review is that it categorically intends to provide a critical appraisal on the said available experimental data within the variables of breast cancer and osteoporosis among females vis-à-vis the potentials of functional foods.
El texto completo de este artículo está disponible en PDF.Abbreviations : AP, APC, ATM, BDNF-AS, BIN1, BMP6, BRCA, CpG, DMBA, ER, GSTP1, HER2, HOTAIR, MALAT1, PTEN, PR, PVT1, RANKL, SP-1, TNFSF11, TP53, UCA1
Keywords : Breast cancer, Postmenopausal, Osteoporosis, Links, Functional foods, Effects
Esquema
Vol 107
P. 571-582 - novembre 2018 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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