The purpose of the present review was to integrate the available data published on ameloblastic fibrodentinosarcoma (AFDS) and ameloblastic fibro-odontosarcoma (AFOS) into a comprehensive analysis of their clinical/radiologic features. An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. Seventeen publications (8 AFDS, 9 AFOS) were included. The patients with the two different lesions had a similar mean age. The lesions were both more prevalent in mandibles than in maxillae, all showed bone expansion and similar rates of cortical bone perforation, tooth displacement, and locular appearance at radiological exams. Mean follow-up time was higher for AFDS, and the mean size of the lesions were larger for AFDS, although without a statistically significant difference. None of AFDS recurred, while 2 AFOS recurred. As only few cases of AFDS and AFOS have been reported, additional reports are necessary to add evidence to the study of clinical and radiologic features of these lesions.