The arrival of predictive biomarkers for monitoring therapy response to natural compounds in cancer drug discovery - 09/12/18
, Atanas G. Atanasov c, d, e, Mariam Amrani f, Said Afqir b, gBienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
| páginas | 7 |
| Iconografías | 5 |
| Vídeos | 0 |
| Otros | 0 |
Graphical abstract |
Highlights |
• | Management of cancers in advanced stages is a major challenge in daily practice of oncologists. |
• | Anticancer drugs from natural sources such as trabectedin showed promising activities in randomized and controlled clinical trials. |
• | Cancer biomarkers were recently developed for optimizing the use of these therapeutic agents and predicting their response. |
Abstract |
Intrinsic or acquired drug resistance, adverse drug reactions and tumor heterogeneity between and within cancer patients limit the efficacy of clinical management of advanced cancers. To overcome these barriers, predictive biomarkers have recently emerged to guide medical oncologists in the selection of cancer patients who will respond to various anticancer treatments and to improve the toxicity to benefit ratio. Notably, targeted therapy has significantly benefited from these advances, but the application of predictive biomarkers have been a bit slower with some drugs derived from natural sources such as trabectedin, cabazitaxel and alvocidib. In this paper, we discuss some recent advances regarding the use of cancer biomarkers to predict efficacy of some selected natural compounds with a focus on human clinical studies.
El texto completo de este artículo está disponible en PDF.Abbreviations : AR-V7, BRAF, BRCA1, BRCA2, CA4P, CDK9, CTCs, CUL4A, CXCL12, CXCR4, DCE-MRI, DNA, eEF1A2, EPR, FDA, JNK, MCL-1, MMP-9, MOBILE, PARP, PARP1, PDGFR, PD-L1, PLD, RAS, RECIST, REMARK, STS, TAMs, TIE-2, TIMP1, TIMP2, VEGF
Keywords : Predictive biomarkers, Anticancer natural compounds, Therapy response, Cancer drug discovery
Esquema
Vol 109
P. 2492-2498 - janvier 2019 Regresar al número
Artículo precedente
- Wild edible onions — Allium flavum and Allium carinatum — successfully prevent adverse effects of chemotherapeutic drug doxorubicin
- Pavić Aleksandar, Mitić-Ćulafić Dragana, Jasnić Nebojša, Nikolić Biljana, Simin Nataša, Vasiljević Branka, Knežević-Vukčević Jelena
- Ivabradine possesses anticonvulsant and neuroprotective action in mice
- Talita Matias Barbosa Cavalcante, José de Maria Albuquerque De Melo, Lia Bastos Lopes, Matheus Costa Bessa, Jéssica Gurgel Santos, Luna Costa Vasconcelos, Antônio Eufrásio Vieira Neto, Lucas Teixeira Nunes Borges, Marta Maria França Fonteles, Adriano José Maia Chaves Filho, Danielle Macêdo, Adriana Rolim Campos, Carlos Clayton Torres Aguiar, Silvânia Maria Mendes Vasconcelos
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?