Intracranial aneurysms in sickle cell disease: Aneurysms characteristics and modalities of endovascular approach to treat these patients - 05/04/19

Doi : 10.1016/j.neurad.2019.03.001

Sophie Gallas ^a,^⁎ , Titien Tuilier ^a, Vahid Ebrahiminia ^b, Pablo Bartolucci ^c, Jérôme Hodel ^a, André Gaston ^a
^a CHU de Henri-Mondor, Créteil, AP–HP, service de neuroradiologie diagnostique et thérapeutique, 94000 Créteil, France
^b CHU de Henri-Mondor, Créteil, AP–HP, Service informatique et statistique, 94000 Créteil, France
^c CHU de Henri-Mondor, Créteil, AP–HP, service d’hématologie et de pathologie du globule rouge, 94000 Créteil, France

^⁎Corresponding author at: CHU de Henri-Mondor, Créteil, AP–HP, service de neuroradiologie, 94010 Creteil, France.CHU de Henri-Mondor, Créteil, AP–HP, service de neuroradiologieCreteil94010France

En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Friday 05 April 2019
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Abstract

Introduction

The neurological complications of Sickle Cell Disease (SCD) include cerebral infarction and haemorrhage with rarely subarachnoid haemorrhage due to cerebral aneurysms.

Materials and methods

In our interventional department, working with SCD referral department, we reported our experience concerning management of adult's patients with cerebral aneurysms. We identified 26 adults with 48 intracranial aneurysms documented by imaging.

Results

18 patients, with 26 cerebral aneurysms were treated by endovascular approach for their aneurysms. No patient was treated by surgical way in our institution. 50% of patients had multiple aneurysms. Locations of aneurysms treated were typical with 70% of cerebral anterior artery and 30% of posterior artery. Three patients suffered from subarachnoid haemorrhage. Two procedure-related complications occurred during the treatment: one thrombo-embolic event with good recovery after medical treatment and one aneurismal perforation leading to the death of patient. Hypercoagulability is a major specific risk in SCD and use of permanent device as stent of flow diverter should be discussed to prevent complications.