The emerging roles of eryptosis in liver diseases - 12/06/19

Doi : 10.1016/j.tracli.2019.05.004

Wei Xu ^a, Fang Peng ^b, Ying Deng ^c, Xuegong Fan ^d, Ning Li ^a,^⁎
^a Department of Blood Transfusion, Central South University, Xiangya Hospital, 410008 Changsha, China
^b Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Central South University, Xiangya Hospital, 410008 Changsha, China
^c The Hospital of Ningxiang County People, 410600 Changsha, China
^d Department of Infectious Diseases, Key Laboratory of Viral Hepatitis of Hunan Province, Central South University, Xiangya Hospital, 410008 Changsha, China

^⁎Corresponding author.

En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Wednesday 12 June 2019
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Abstract

Erythrocytes undergo programmed cell death, similar to apoptosis, known as eryptosis. This process is a result of several factors including hyperosmolarity, oxidative stress, and exposure to xenobiotics, and is characterized by the breakdown of membrane phospholipid asymmetry, the clustering of band 3, and the generation of red blood cell-derived microparticles. Under pathological conditions, the liver is the primary site of erythrocyte clearance and plays an important role in iron recycling. Phosphatidylserine exposure and band-3 clustering on eryptotic erythrocytes represent mainly pro-phagocytic signals. Further, the percentage of eryptotic erythrocytes is enhanced in the circulating blood of patients with hepatic failure, hyperbilirubinemia, and nonalcoholic steatohepatitis. In this review, we concentrate on recent progress regarding the pathophysiological roles of eryptosis in liver diseases.

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Keywords : Eryptosis, Macrophages, Liver disease, Microparticles

Abbreviations : RMPs, HSECs, PS, HRG1, FPN, FLVCR1, TNF-α, TNF-β, IL-6, IL-1β