A multifaceted exercise intervention did not alter cognitive function and cerebral perfusion in individuals with Parkinson's disease - 13/07/19

Une intervention à multiples facettes n’a pas modifié la fonction cognitive et la perfusion cérébrale chez les personnes atteintes de la maladie de Parkinson

Doi : 10.1016/j.scispo.2019.05.008

B.S. Pollock ^a,^d,^e,^⁎ , C.A. Peacock ^b, E.J. Ryan ^c, M.B. Spitznagel ^d, A.L. Ridgel ^a
^a Department of Exercise Physiology, Kent State University, 350 Midway Drive, Kent, OH, USA
^b Department of Health and Human Performance, Nova Southeastern University, 3301 College Avenue, Fort Lauderdale, FL, USA
^c Department of Human Performance, West Virginia School of Medicine, 1 Medical Center Drive, Morgantown, WV, USA
^d Department of Psychological Sciences, Kent State University, 600 Hilltop Drive, Kent, OH, USA
^e School of Behavior and Health Sciences, Walsh University, 2020 E. Maple Street, North Canton, OH, USA

^⁎Corresponding author at: School of Behavior and Health Sciences, Walsh University, 2020 E. Maple Street, North Canton, OH, USA.School of Behavior and Health Sciences, Walsh University2020 E. Maple StreetNorth CantonOHUSA

En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Saturday 13 July 2019
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Summary

Objectives

To investigate cerebral perfusion as a potential mechanism of exercise-related cognitive improvements and to further associate cognition and cerebral perfusion in Parkinson's disease.

Equipment and methods

Cerebral perfusion was measured continuously at rest and during a cognitive task using near-infrared spectroscopy before and after a multifaceted exercise program in thirteen individuals with Parkinson's disease.

Results

Cognitive function was not significantly impaired in our group of Parkinson's disease participants at baseline. Cerebral perfusion (69.91%±2.43) was significantly greater during cognitive testing than while resting (68.12%±2.42) (P≤0.001). Our results are inconclusive with respect to the effect of exercise on cognitive dysfunction in PD.

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Résumé

Objectifs

Investiguer la perfusion cérébrale comme un mécanisme potentiel de l’amélioration cognitive liée à l’exercice et associer davantage la cognition et la perfusion cérébrale dans la maladie de Parkinson.

Matériel et méthodes

La perfusion cérébrale a été mesurée en permanence au repos et au cours d’une tâche cognitive en utilisant la spectroscopie proche infrarouge avant et après un programme d’exercices à multiples facettes chez treize personnes atteintes de la maladie de Parkinson.

Résultats

La fonction cognitive n’était pas significativement altérée chez notre groupe de participants à la maladie de Parkinson au départ. La perfusion cérébrale (69,91 %±2,43) était significativement plus élevée pendant les tests cognitifs que pendant le repos (68,12 %±2,42) (p≤0,001). Nos résultats ne sont pas concluants en ce qui concerne l’effet de l’exercice sur la dysfonction cognitive dans la maladie de Parkinson.

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Keywords : Exercise, Cognition, Cerebrovascular circulation, Parkinson disease

Mots clés : Exercice, Cognition, Circulation cérébrovasculaire, Maladie de Parkinson