Is multiple sclerosis a risk factor for atherosclerosis? - 27/11/19
This article has been published in an issue click here to access
Graphical abstract |
Box-plot representing right and mean CIMT in patient and control groups. CIMT: carotid intima-media thickness.
El texto completo de este artículo está disponible en PDF.Highlights |
• | CIMT seemed to be affected in patients with MS when comparing with healthy controls.who had similar demographic variables (age, sex, body mass index [BMI], blood pressure, and cholesterol levels). |
• | During remission Hs-CRP has been found at normal levels. |
• | Different disease-modifying therapies may have altered the inflammation process. |
Abstract |
Background |
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. We aimed to discuss possible predisposing factors to atherosclerosis such as carotid intima-media thickness (CIMT) and high-sensitivity C-reactive protein (Hs-CRP) levels in MS.
Methods |
Thirty-five ambulatory patients with relapsing-remitting MS (RRMS) (22 females and 13 males) and 34 healthy controls (21 females and 13 males) with similar demographic variables were included. Blood cell counts, cholesterol levels, vitamin D and B12, Hs-CRP levels, body mass index (BMI), history of smoking, and CIMT of both groups, Expanded Disability Status Scale (EDSS) scores, and disease duration of patients were recorded. Patients with a history of other vascular diseases such as hypertension, diabetes mellitus, peripheral artery disease, and acute relapses were excluded.
Results |
Sixty-nine participants were included. The mean age of the study population was 35.8±7.1 years. Right CIMT was significantly greater in the patient population (P<0.001). Spearman's correlation coefficient between age and right CIMT was r=0.41, P=0.01. When we compared the Hs-CRP with a cut-off value of ≤3, the right, left, and mean CIMT levels were not statistically significant (P=0.17; P=0.22; P=0.15). The mean serum vitamin D levels were higher in the patient group and this was statistically significant (P<0.001). The statistically significant factors identified with univariate analysis with P<0.2 were further entered into multivariate modelling.
Conclusion |
CIMT seems to be affected in patients with MS by means of the disease itself and age. Thus, CIMT might reflect the predisposition to subclinical atherosclerosis more than Hs-CRP. Further investigation in a large MS population is still needed.
El texto completo de este artículo está disponible en PDF.Keywords : Atherosclerosis, Multiple sclerosis, Intima-media thickness, High-sensitivity C-reactive protein, Inflammation
Esquema
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
¿Ya suscrito a @@106933@@ revista ?