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Antioxidant and antifungal activities of marrubiin, extracts and essential oil from Marrubium vulgare L. against pathogenic dermatophyte strains - 24/01/20

Doi : 10.1016/j.mycmed.2020.100927 
M. Rezgui a, , N. Majdoub a, B. Mabrouk a, A. Baldisserotto b, A. Bino b, L.B. Ben Kaab a, S. Manfredini b
a Faculty of Sciences of Tunisia, University Tunis El Manar, 2092 Tunis, Tunisia 
b School of Pharmacy and Health Products, Department of Life Sciences and Biotechnology, University of Ferrara, Master Course in Cosmetic Sciences and Technology, Laboratory of Health Products, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy 

Corresponding author.
En prensa. Pruebas corregidas por el autor. Disponible en línea desde el vendredi 24 janvier 2020

Abstract

Objective

Medicinal plants extracts and plant-derived compounds are one of the natural sources for discovering new antifungal agents, the objectives of this work were to investigate for the first time the antidermatophytic, antipathogenic activities of methanol, acetone extracts, and essential oil of Marrubium vulgare L. grown in Tunisia and its active compound marrubiin on pathogenic for animals and humans, such as some dermatophytes and pathogenic for plants, and to evaluate antioxidant activities of different extracts with consideration to their chemical compositions.

Material and methods

Acetone and methanol extracts were evaluated by HPLC, the essential oil was also analyzed by GC/MS. PCL assay was used to determine the antioxidant activity.

Results

Results showed that methanol and acetone extracts exhibited a significant antioxidant activity (261.41 and 272.90μmol TE/g respectively), while the lowest one was observed in the case of marrubiin and essential oil. The antifungal activity of different extracts, marrubiin and essential oil at two concentrations (20 and 100μg/mL) were screened against the dermatophytes fungi Microsporum gypseum, Microsporum canis, Arthroderma cajetani, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum and against two fungi strains (Botrytis cinerea, Pythium ultimum). Among tested extracts, marrubiin at 100μg/mL showed about 50% inhibition for T. mentagrophytes and E. floccosum. The anti-phytopathogenic activity was also carried out, only marrubiin had in activity against B. cinerea at the highest dose (32.40%), while methanol extract of M.vulgare and marrubiin are able to increase the mycelial growth of P. ultimum at the highest concentration (45.15 and 40.30% respectively).

Conclusion

In our study, we conclude that M.vulgare and marrubiin can be used as natural antioxidants and antifungal agent for treatment of skin dermatophyte infections.

El texto completo de este artículo está disponible en PDF.

Keywords : Antioxidant activity, Dermatophytes, Essential oil, M. vulgare, Marrubiin


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