Exploring the molecular mechanism of azole resistance in Aspergillus fumigatus - 10/04/20
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Abstract |
Aspergillus infections are increasingly recognized as a global health problem because of limited antifungal drugs and occurrence of azole resistance worldwide. More cyp51-mediated and non-cyp51-mediated mechanisms of azole resistance have been identified in clinical and laboratory studies in recent years with applications of molecular biotechnology including next-generation sequencing, reverse genetics and so on. In this review, current research on the molecular mechanisms of azole resistance in A. fumigatus were presented and summarized and meanwhile the putative clinical relevance of these findings from bench work were discussed. Important aims are to gain more insight to mechanism of azole resistance and provide some efficient lead for prevention strategy.
El texto completo de este artículo está disponible en PDF.Keywords : Pathogenic fungi, Aspergillus fumigatus, Azole resistance, cyp51 mutation, Non-cyp51 mutation
Esquema
Vol 30 - N° 1
Artículo 100915- avril 2020 Regresar al número
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