Effet préventif de l’infection de la poudre de vancomycine dans le site opératoire au cours des arthroplasties totales du genou primaire - 04/05/20
Role of intrawound powdered vancomycin in primary total knee arthroplasty
Abstract |
Background |
No study has evaluated the effect of topical powdered vancomycin in patients undergoing primary total knee arthroplasty (TKA). The goal of this study is to determine if this method reduces postoperative infection rates following primary TKA.
Patients and methods |
This retrospective study reviewed 855 consecutive patients undergoing TKA. The first 418 patients did not receive topical vancomycin were grouped into the control group, and the subsequent 437 patients received powdered vancomycin applied to the target joint prior to wound closure were grouped into the treatment group.
Results |
The control group was found to have 18 infectious complications (4.3%) compared with 6 (1.4%) in the treatment group, which differed significantly (p<0.05). When comparing the rates of infectious complications independently, there was no significant difference in the rate of superficial infection (3.1% vs. 1.4%; p>0.05), while the difference in prevalence of periprosthetic joint infection (PJI) was statistically significant (1.2% vs. 0; p<0.05). No serious adverse events (AEs) occurred.
Discussion |
Topical application of powdered vancomycin may present a reasonable means of decreasing the risk of infectious complications following TKA. There were no serious AEs associated with topical vancomycin. Further research is needed to focus on its long-term efficacy and safety.
Level of evidence |
β, retrospective, cohort study.
El texto completo de este artículo está disponible en PDF.Keywords : Topical powdered vancomycin, Periprosthetic joint infection (PJI), Total knee arthroplasty (TKA), Wound complications, Superficial infection
| ☆ | Cet article peut être consulté in extenso dans la version anglaise de la revue Orthopaedics & Traumatology: Surgery & Research sur Science Direct (sciencedirect.com) en utilisant le DOI ci-dessus. |
Vol 106 - N° 3
P. 213 - mai 2020 Regresar al número
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