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New understanding of the damage of SARS-CoV-2 infection outside the respiratory system - 30/05/20

Doi : 10.1016/j.biopha.2020.110195 
Yuhao Zhang a, 1, Xiuchao Geng b, 1, Yanli Tan a, Qiang Li c, Can Xu a, Jianglong Xu a, Liangchao Hao a, Zhaomu Zeng a, Xianpu Luo d, Fulin Liu e, , Hong Wang a, f,
a School of Medicine, Hebei University, Baoding, 071000, China 
b Faculty of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China 
c Faculty of Acupuncture-Moxibustion and Tuina, Hebei University of Chinese Medicine, Shijiazhuang, 050200, China 
d Ncbio-Medicine Cooperation, Beijing, 100000, China 
e Office of Academic Research, Affiliated Hospital of Hebei University, Baoding, 071000, China 
f Faculty of Integrated Traditional Chinese and Western Medicine, Hebei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang, 050091,China 

Corresponding author at: Faculty of Integrated Traditional Chinese and Western Medicine, Hebei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular Disease, Hebei University of Chinese Medicine, 326 Xinshi south road, Shijiazhuang, 050091, China.Faculty of Integrated Traditional Chinese and Western MedicineHebei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular DiseaseHebei University of Chinese Medicine326 Xinshi south roadShijiazhuang050091China⁎⁎Corresponding author at: Office of Academic Research, Affiliated Hospital of Hebei University, 212 Yuhua east road, Baoding, 071000, China.Office of Academic ResearchAffiliated Hospital of Hebei University212 Yuhua east roadBaoding071000China

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El texto completo de este artículo está disponible en PDF.

Highlights

SARS-CoV-2 is a kind of systemic virus, and lungs are not the only target organ.
SARS-CoV-2 attacks digestive system, urogenital system, nervous system and circulatory system.
Some new mechanisms about SARS-CoV-2 invading human cell.
SARS-CoV-2 plays an important role in “Inflammatory Cascade”.

El texto completo de este artículo está disponible en PDF.

Abstract

Since early December 2019, a number of pneumonia cases associated with unknown coronavirus infection were identified in Wuhan, China, and many additional cases were identified in other regions of China and in other countries within 3 months. Currently, more than 80,000 cases have been diagnosed in China, including more than 3000 deaths. The epidemic is spreading to the rest of the world, posing a grave challenge to prevention and control. On February 12, 2020, the International Committee on Taxonomy of Viruses and the World Health Organization officially named the novel coronavirus and associated pneumonia as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19), respectively. According to the recent research on SARS-CoV-2, the virus mainly infects the respiratory system but may cause damage to other systems. In this paper, we will systematically review the pathogenic features, transmission routes, and infection mechanisms of SARS-CoV-2, as well as any adverse effects on the digestive system, urogenital system, central nervous system, and circulatory system, in order to provide a theoretical and clinical basis for the diagnosis, classification, treatment, and prognosis assessment of SARS-CoV-2 infection.

El texto completo de este artículo está disponible en PDF.

Keywords : SARS-CoV-2, COVID-19, Digestive system, Urogenital system, Central nervous system, Circulatory system


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© 2020  The Author(s). Publicado por Elsevier Masson SAS. Todos los derechos reservados.
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Vol 127

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