Role and mechanism of LAIR-1 in the development of autoimmune diseases, tumors, and malaria: A review - 19/08/20
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Abstract |
The levels of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), a type I transmembrane glycoprotein broadly expressed on the majority of hematopoietic cells, such as T/B cells and natural killer cells, vary significantly during cell differentiation and activation. Previous studies focused mainly on the role of LAIR-1 in physiology and some pathological conditions, including autoimmune diseases. It has been shown that LAIR-1 mediates immune suppression, further resulting in uncontrolled inflammation. Furthermore, recent studies showed that LAIR-1 participates in the development of hematopoietic and non-hematopoietic tumors as well as malaria. This review summarizes the current findings on LAIR-1 in various diseases, its potential roles in pathogenesis, and provides new insight into the treatment of patients through suppression of the function of LAIR-1.
El texto completo de este artículo está disponible en PDF.Keywords : Leukocyte-associated immunoglobulin-like receptor-1, Autoimmune diseases, Tumor, Malaria, Inhibitory receptor
Esquema
Vol 68 - N° 3
P. 119-124 - août 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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