Anti-TNF containing regimens may be associated with increased risk of Clostridioides difficile infection in patients with underlying inflammatory bowel disease - 19/08/20
, Hamid Asadzadeh Aghdaei a, Masoumeh Azimirad b, Nasser Ebrahimi Daryani c, Mohammad Reza Zali dBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Highlights |
• | Considerable incidence of CDI in a group of Iranian patients with IBD. |
• | High prevalence of toxigenic C. difficile isolates among patients with IBD. |
• | Potential risk of anti-TNF containing regimens and emergence of CDI. |
Abstract |
Background |
Patients with inflammatory bowel disease (IBD) are at greater risk for Clostridioides difficile infection (CDI). There remain controversial issues about the association of infliximab therapy in IBD patients and CDI.
Objective |
The present work aimed to investigate the potential association between infliximab therapy and the risk of CDI in a group of Iranian patients with IBD.
Patients and methods |
A total of 140 IBD patients were enrolled, their fresh stool specimens were obtained and used for C. difficile detection. The presence of toxin-encoding genes of C. difficile isolates were examined by PCR. Demographic data, frequency of defecation, antibiotic usage, and IBD therapy were recorded.
Results |
About half of the IBD patients had a history of antibiotic usage, mostly metronidazole (11.4 %) alone, and metronidazole + ciprofloxacin (16.4 %) as drug combination. C. difficile was isolated from 17.1 % (24/140) of the IBD patients, and more than 90 % of the isolates were found to be toxigenic having genotypes of tcdA+/tcdB+ (18/22, 81.8 %), tcdA+/tcdB− (3/22, 13.6 %) and tcdA−/tcdB+ (1/22, 4.5 %). Interestingly, we only found a significant relationship between the emergence of CDI and the use of infliximab in combinations with other drugs (P = 0.023).
Conclusions |
In conclusion, there was a considerable incidence of CDI in Iranian patients with IBD. Our study also demonstrated that anti-TNF containing regimens in combinations with other immunosuppressive medications potentially may influence susceptibility to CDI in a group of patients with underlying IBD. Furthermore, our findings recommend avoiding the prolonged use of infliximab along with other corticosteroids or immunomodulators. Further validation studies are needed to better understand the mechanisms that regulate TNF-mediated pathways in CDI pathogenesis among IBD patients.
El texto completo de este artículo está disponible en PDF.Keywords : Clostridioides difficile infection, Inflammatory bowel disease, Anti-TNF therapy, Infliximab, Immunosuppressive drugs
Esquema
Vol 68 - N° 3
P. 125-130 - août 2020 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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