Pre-surgical embolization of intracranial meningioma with Onyx: A safety and efficacy study - 21/08/20
, Victor Hugo Espíndola Ala a, Leslie Lemnos b, Suzana Saleme a, Mathilde Duchesne c, Henri Salle b, François Caire b, Charbel Mounayer a, d, Aymeric Rouchaud a, dBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Graphical abstract |
Abstract |
Background and purpose |
Pre-surgical embolization of large intracranial meningioma has been demonstrated to decrease blood loss and to improve the resectability of the tumor. Few reports have evaluated the risk and benefits of using Onyx in this indication. The objective of our study was to assess the efficiency and safety of pre-surgical embolization in a consecutive series of intracranial meningioma using Onyx.
Materials and methods |
We conducted a retrospective study of consecutive patients treated from 2010 to 2018 with pre-surgical embolization with Onyx for intracranial histologically-proven meningioma. Safety was evaluated by a report of the complications related to the procedure while efficacy was assessed on angiographic and histopathologic criteria.
Results |
Forty-four meningioma in 44 patients treated with pre-surgical embolization were included in this study. Proximal artery occlusion was obtained in 97.6% (41/42) of the cases and good intra-tumoral penetration was achieved in 75.6% (31/41). Embolic agent inside blood vessels was identified in 63.5% (28/44) of cases. Embolization-induced necrosis was present in 79.6% (35/44) of cases. Six complications have been encountered (13.6%); 3 were stated as minor complications (6.8%) and 3 as major occurring in case of trans-ophthalmic route (6.8%).
Conclusions |
The present work is to date the largest study to evaluate intracranial meningioma embolization using Onyx. Onyx's allowed good intra-tumoral penetration and proximal artery occlusion in most cases but carries a higher risk of complication in case of ophthalmic supply.
El texto completo de este artículo está disponible en PDF.Keywords : Ethylene-vinyl alcohol copolymer, Embolization, Therapeutic, Meningioma, Intracranial
Abbreviations : DMSO, EVOH, PTBE, WHO
Esquema
| ☆ | Presentation in part or whole at any meeting: abstract submitted for the 46th annual congress of the French Society of Neuroradiology. |
Vol 47 - N° 5
P. 353-357 - septembre 2020 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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