The role of long non-coding RNA MIAT in cancers - 28/08/20
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Highlights |
• | This paper reviews the recent literature on MIAT. |
• | According to the classification of disease, mechanism and prognosis, the role of MIAT in cancer field was summarized. |
• | It is concluded that MIAT is a potential biomarker of human cancer and may become a potential target for cancer diagnosis and treatment. |
• | This review is valuable to all who are engaged in this field. |
Abstract |
Long non-coding RNAs (lncRNAs), a kind of non-coding single-strand RNAs, play an important role as carcinogenic genes or tumor suppressors in the development of human cancer. Myocardial infarction-associated transcript (MIAT) was first identified as a lncRNA in 2006 and originally isolated as a candidate gene for myocardial infarction. Later, it was reported that MIAT exhibits regulatory effects on the human cell cycle. Since its discovery, MIAT has also been identified as a carcinogenic regulator in many malignant tumors. High expression of MIAT is related to the clinicopathological characteristics of cancer patients. It can also regulate cell proliferation, invasion, metastasis, and anti-apoptosis through a variety of mechanisms. Therefore, MIAT is considered a potential biomarker and therapeutic target in cancer. In this review, we summarize the biological function, mechanism, and potential clinical significance of MIAT during tumorigenesis.
El texto completo de este artículo está disponible en PDF.Keywords : MIAT, LncRNA, Cancer, Biomarker
Esquema
Vol 129
Artículo 110359- septembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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