Qingda granules attenuate hypertensive cardiac remodeling and inflammation in spontaneously hypertensive rats - 28/08/20
páginas | 8 |
Iconografías | 9 |
Vídeos | 0 |
Otros | 0 |
Graphical abstract |
Highlights |
• | Simplified from QXJYD, QDG treatment obviously attenuates elevated blood pressure in SHRs. |
• | QDG treatment ameliorates cardiac fibrosis and inflammation of SHRs. |
• | QDG treatment inhibits the activation of NF-κB pathway and alternates multiple endogenous metabolites. |
Abstract |
Qingda granules (QDG) are derived from QingXuanJiangYa Decoction (QXJYD) a traditional Chinese medication that has been used to treat hypertension for more than 60 years. QXJYD has been shown to be effective in rat models of hypertension. However, the effects of QDG on hypertension remain largely unknown. In the current study, baicalin was identified as one of the main components of QDG using Ultra Performance Liquid Chromatography (UPLC) analysis. We investigated the effects of QDG on blood pressure, cardiac remodeling, and cardiac inflammation. QDG (0.8 g/kg/day) treatment attenuated the elevated blood pressure in spontaneously hypertensive rats (SHRs). Moreover, QDG treatment reduced the degree of myocardial fiber disarray, degeneration and necrosis of myocardial cells, expression of ANP and BNP, as well as collagen content of SHRs. Moreover, we further assessed the effect of QDG treatment on cardiac inflammation and found that QDG treatment reduced CD68 protein expression, decreased levels of IL-6 and TNF-α in both serum and cardiac tissues, as well as suppressed activation of NF-κB pathway in cardiac tissues of SHRs. Differential expressed metabolites (DEMs) analysis identified 41 increased and 51 decreased metabolites in the cardiac tissues of SHRs after QDG treatment. In summary, QDG treatment of SHRs attenuated the elevated blood pressure and ameliorated cardiac remodeling and inflammation, in part, through suppression of NF-κB pathway and DEMs, which provide a basis for other therapeutic uses of this TCM.
El texto completo de este artículo está disponible en PDF.Keywords : Qingda granules, Hypertension, Cardiac remodeling, Inflammation, NF-κB pathway, Metabolite
Esquema
Vol 129
Artículo 110367- septembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?