Chinese herbal medicine Baoyuan Jiedu decoction inhibits the accumulation of myeloid derived suppressor cells in pre-metastatic niche of lung via TGF-?/CCL9 pathway - 28/08/20
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Graphical abstract |
Potential mechanisms of Baoyuan Jiedu decoction to improve pre-metastatic niche.
Baoyuan Jiedu decoction inhibits the accumulation of MDSC in pre-metastatic niche of lung via TGF-β/CCL9 pathway.
Highlights |
• | Baoyuan Jiedu decoction reverses the pre-metastatic niche of lung. |
• | Baoyuan Jiedu decoction inhibits the accumulation of MDSC in pre-metastatic niche of lung. |
• | Baoyuan Jiedu decoction downregulates TGF-β/CCL9 pathway activation. |
Abstract |
Baoyuan Jiedu (BYJD for short) decoction, a traditional Chinese medicine formula, is composed of Astragalus, Ginseng, Aconite root, Honeysuckle, Angelica, Licorice, which has the functions of nourishing qi and blood, enhancing immune function, improving quality of life and prolonging survival time of tumor patients. The present study aimed to investigate the effect and mechanism of BYJD decoction on reversing the pre-metastatic niche. We showed that BYJD decoction could prolong the survival time of 4T1 tumor-bearing mice. Moreover, we found that the BYJD decoction inhibited the formation of lung pre-metastatic niche and inhibited recruitment of myeloid derived suppressor cells (MDSCs) in the lung. Mechanistically, we showed that the proteins and genes expression of TGF-β, Smad2, Smad3, p-Smad2/3, Smad4, CCL9 in the TGF-β/CCL9 signaling pathway were suppressed by BYJD decoction. In line with the above findings, our results confirm that BYJD decoction inhibits the accumulation of MDSC in pre-metastatic niche of lung via TGF-β/CCL9 pathway.
El texto completo de este artículo está disponible en PDF.Keywords : Pre-metastatic niche, Traditional Chinese Medicine, Myeloid derived suppressor cells, TGF-β/CCL9 signaling pathway
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Vol 129
Artículo 110380- septembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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