Study on the relationship between hepatic fibrosis and epithelial-mesenchymal transition in intrahepatic cells - 28/08/20
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Graphical abstract |
Highlights |
• | Many substances, including miRNAs, regulate EMT via transcriptional controls. |
• | The EMT signaling pathways TGF-β, Notch and Hh exhibited significant effects. |
• | Type II EMT occurs in HSCs, HCs, and BECs, promoting liver fibrosis. |
• | The HSC, HC, and BEC intrahepatic cells are significant in liver fibrosis. |
Abstract |
Hepatic fibrosis is a pathophysiological process, which causes excessive extracellular matrix (ECM) deposition resulting from persistent liver damage. Myofibroblasts are the core cells that produce ECM. It is known that epithelial-mesenchymal transition (EMT) is not a simple transition of cells from the epithelial to mesenchymal state. Instead, it is a process, in which epithelial cells temporarily lose cell polarity, transform into interstitial cell-like morphology, and acquire migration ability. Hepatocytes, hepatic stellate cells, and bile duct cells are the types of intrahepatic cells found in the liver. They can be transformed into myofibroblasts via EMT and play important roles in the development of hepatic fibrosis through a maze of regulations involving various pathways. The aim of the present study is to explore the relationship between the relevant regulatory factors and the EMT signaling pathways in the various intrahepatic cells.
El texto completo de este artículo está disponible en PDF.Keywords : Hepatic fibrosis, Epithelial-mesenchymal transition, Hepatocytes, Hepatic stellate cells, Bile duct cells, Mechanism research
Esquema
Vol 129
Artículo 110413- septembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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