The oncogenic role of Jagged1/Notch signaling in cancer - 28/08/20
, Yuan-meng Liu , Bo-hai Kuang ⁎ Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
| páginas | 11 |
| Iconografías | 2 |
| Vídeos | 0 |
| Otros | 0 |
Abstract |
Aberrant activation of Notch signaling plays an oncogenic role in cancer development. Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell interactions. JAG1 overexpression has been reported in many different types of cancer and correlates with a poor clinical prognosis. JAG1/Notch signaling controls oncogenic processes in different cell types and cellular contexts. Furthermore, JAG1/Notch signaling cascades activate a number of oncogenic factors that regulate cellular functions such as proliferation, metastasis, drug-resistance, and angiogenesis. To suppress the severe toxicity of pan-Notch inhibitors, JAG1 is attracting increasing attention as a source of therapeutic targets for cancers. In this review, the oncogenic role of JAG1/Notch signaling in cancer is discussed, as well as implications of strategies to inhibit JAG1/Notch signaling activity.
El texto completo de este artículo está disponible en PDF.Abbreviations : HBx, HGF, Met, STAT3, EGFR, MAPK, ERK, PDGF, NOS, Id4, TGF-β, HIF-1α, PKCα, TCGA, NF-κB, SOX2, YAP1, TEAD4, KDM4C, Akt, ADAM17, HTLV
Keywords : JAG1, Notch, Oncogenic, Therapy, Cancer
Esquema
Vol 129
Artículo 110416- septembre 2020 Regresar al número
Artículo precedente
- Study on the relationship between hepatic fibrosis and epithelial-mesenchymal transition in intrahepatic cells
- Yang Chen, Yu Fan, Dong-yan Guo, Bing Xu, Xiao-yan Shi, Jing-tao Li, Li-fang Duan
- Exosomes: Multiple-targeted multifunctional biological nanoparticles in the diagnosis, drug delivery, and imaging of cancer cells
- Yuzhong Zheng, Anwarul Hasan, Mohammad Mahdi Nejadi Babadaei, Elham Behzadi, Mina Nouri, Majid Sharifi, Mojtaba Falahati
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?