Improvement of antioxidant activity of oregano (Origanum vulgare L.) with an oral pharmaceutical form - 28/08/20
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Graphical abstract |
Highlights |
• | Origanum vulgare L. hydroalcoholic extract shows antioxidant activity in vitro and in vivo. |
• | Oral formulation of oregano preserves antioxidant activity from gastrointestinal digestion. |
• | Encapsulation improve antioxidant activity of O. vulgare in C. elegans. |
• | Rosmarinic acid and 3,4-dihydroxybenzoic acid seem to be the major bioactive compounds of O. vulgare, even after digestion. |
Abstract |
Aging-related diseases can be triggered by multiple factors such as oxidative stress. Oxidative stress is an imbalance between free radicals and antioxidants, so today, compounds capable of reducing or neutralizing free radicals are being studied for a therapeutic use. Origanum vulgare L. is a traditional medicinal plant used for a wide number of health problems due to its antimicrobial, carminative and antioxidant activities. However, when administered orally, gastrointestinal digestion can modify some of therapeutical properties. To avoid this, two different solid oral formulations have been designed for an O. vulgare extract evaluating their antioxidant behaviours in vitro and in vivo after a simulation of gastrointestinal digestion. The results showed that the divided powder has a lower antioxidant activity both in vitro and in vivo than the encapsulated extract. The quantitative difference of polyphenols found on HPLC-DAD (especially luteolin, apigenin and caffeic acid) may explain the differences in pharmacological activity. Thus, we propose that the best form to administrate O. vulgare extracts to maintain the antioxidant properties is the encapsulated form, that is, two capsules of 250 mg of a hydroalcoholic extract of O. vulgare with a minimum of 33 % of rosmarinic acid as a daily dose.
El texto completo de este artículo está disponible en PDF.Abbreviations : OV-E, OV-C, OV-P
Keywords : C. elegans, Antioxidant, O. vulgare, Formulation, Digestion
Esquema
Vol 129
Artículo 110424- septembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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