Antimicrobial activity of Apis mellifera L. and Trigona sp. propolis from Nepal and its phytochemical analysis - 28/08/20
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Graphical abstract |
Highlights |
• | Nepalese propolis is an efficient antibacterial agent, especially against Staphylococcus aureus and Helicobacter pylori. |
• | Nepalese propolis exhibited synergism with antibiotics against Staphylococci genus. |
• | Nepalese propolis inhibit filamentation of Candida albicans. |
• | Nepalese propolis induces oxidative damages in Candida albicans cells. |
Abstract |
In this study, we evaluated antimicrobial activity, antimicrobial activity in combination with antibiotics, and chemical composition of Nepalese propolis 70% ethanolic extracts. Propolis originated from two genera of bees – Apis mellifera L. and Trigona sp. HPLC-DAD-MS/MS analyses revealed that the composition of both extracts was almost the same and the main components were flavonoid aglycones (mainly neoflavonoids, isoflavonoids) and pterocarpans. The highest antibacterial activity (disc diffusion test) was observed against Helicobacter pylori, Staphylococcus aureus and Shigella flexneri. Antibiotics exhibited synergism with Apis mellifera L. and Trigona sp. propolis against S. aureus and the strongest effect was observed for the combination with amikacin and tetracycline. Moreover, Nepalase propolis inhibited filamentation of C. albicans and caused oxidative stress by production of the superoxide anion radical (O2−) and a lower concentration of the hydroxyl radical (OH).
Propolis extracts are potent antibacterial agents and may be used in combination with antibiotics.
El texto completo de este artículo está disponible en PDF.Keywords : Propolis, Antibacterial and antifungal activity, Dereplication, Antibiotics, Nepal
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Vol 129
Artículo 110435- septembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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