Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols - 28/08/20
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Graphical abstract |
Highlights |
• | Here, we discussed the role of oxidative stress and inflammation in OA pathogenesis. |
• | Here, we discussed the antioxidant and anti-inflammatory activities of polyphenols. |
• | Polyphenolic compounds suppress oxidative stress and inflammation in OA joints. |
• | Polyphenols inhibit the activation of key signaling pathways in OA pathogenesis. |
• | We discuss here the possibility of development of polyphenol(s) for OA management. |
Abstract |
Osteoarthritis (OA) is the most prevalent joint degenerative disease leading to irreversible structural and functional changes in the joint and is a major cause of disability and reduced life expectancy in ageing population. Despite the high prevalence of OA, there is no disease modifying drug available for the management of OA. Oxidative stress, a result of an imbalance between the production of reactive oxygen species (ROS) and their clearance by antioxidant defense system, is high in OA cartilage and is a major cause of chronic inflammation. Inflammatory mediators, such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are highly upregulated in OA joints and induce ROS production and expression of matrix degrading proteases leading to cartilage extracellular matrix degradation and joint dysfunction. ROS and inflammation are interdependent, each being the target of other and represent ideal target/s for the treatment of OA. Plant polyphenols possess potent antioxidant and anti-inflammatory properties and can inhibit ROS production and inflammation in chondrocytes, cartilage explants and in animal models of OA. The aim of this review is to discuss the chondroprotective effects of polyphenols and modulation of different molecular pathways associated with OA pathogenesis and limitations and future prospects of polyphenols in OA treatment.
El texto completo de este artículo está disponible en PDF.Abbreviations : ADAMTS, COX-2, DMM, ECM, GPx, GSH, H2O2, IFN-γ, IL-1RI, IL-1Ra, IL-1β, IL-6, IL-6R, MAPK, MMP, NFκB, eNOS, iNOS, nNOS, NO, NOS, NOXs, NQO1, Nrf2, NSAIDs, OA, PGE2, Prxs, RNS, ROS, SODs, TNF-α, XO
Keywords : Osteoarthritis, Polyphenols, Inflammation, Redox, Nrf2, Chondrocytes
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Vol 129
Artículo 110452- septembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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