A review: Natural polysaccharides from medicinal plants and microorganisms and their anti-herpetic mechanism - 28/08/20
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Graphical abstract |
Highlights |
• | Natural polysaccharides are promising anti-herpes drugs. |
• | The anti-herpes mechanism is mainly to inhibit the life cycle of the virus. |
• | The structure of the polysaccharide affects its anti-herpes virus activity. |
Abstract |
The infections caused by Herpes simplex viruses (HSV-1 and -2) are seriously endangering the health of all human beings. Once infected with these two viruses, it will cause life-long latency in the host, and the continuous recurrence of the infection will seriously affect the quality of life. Moreover, infections with HSV-1 and HSV-2 have been reported to make the body susceptible to other diseases, such as Alzheimer’s disease and HIV. Thus, more attention should be paid to the development of novel anti-HSV drugs. Polysaccharides obtained from medicinal plants and microorganism (both land and sea) are reported to be promising anti-herpes substances. However, their antiviral mechanisms are complex and diverse, which includes direct inhibition of virus life cycle (Adsorption, penetration, genetic material and protein synthesis) and indirectly through improving the body's immunity. And each step of the research processes from extraction to structural analysis contributes to the result in terms of antiviral activity. Therefore, The complex mechanisms involved in the treatment of Herpes simplex infections makes development of new antiviral compounds is difficult. In this paper, the mechanisms of polysaccharides in the treatment of Herpes simplex infections, the research processes of polysaccharides and their potential clinical applications were reviewed.
El texto completo de este artículo está disponible en PDF.Keywords : Herpes simplex, Polysaccharides, Medicinal plants, Microorganisms, Anti-herpetic mechanisms
Esquema
Vol 129
Artículo 110469- septembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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