Effect of Vicenin-2 on ovariectomy-induced osteoporosis in rats - 28/08/20
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Graphical abstract |
Highlights |
• | Osteoporosis is as severe public health distress worldwide. |
• | Vicenin-2, an active compound of many plants with numerous biological activities. |
• | This study showed that Vicenin-2 mitigates osteoporosis in ovariectomized rats. |
• | Vicenin-2 is an ideal candidate for treating bone associated disorders in future. |
Abstract |
In worldwide, osteoporosis has become one of the severe public health distress and over 200 million people get affected by tenderness and fissure during their life period. Vicenin-2 is a naturally occurring flavonoid glycoside present in Moringa oleifera, Peperomia blanda and Ocimum sanctum Linn with numerous biological activities. The present study aims to assess the effect of Vicenin-2 on ovariectomy-induced postmenopausal osteoporosis in female rats. Surgical removal of ovaries was achieved to institute the ovariectomy animal model. The ovariectomized (OVX) animals were alienated into four groups: Control, OVX alone (model), OVX with Vicenin-2 (5 mg/kg b.w), and OVX with Vicenin-2 (10 mg/kg b.w). Also, their consistent conduct remained managed intragastrically for about 12 weeks. OVX rats treated with Vicenin-2 effectually improved body mass, uterus index, lipid profiles, inflammatory markers, bone turnover markers and amplified the presence of calcium in the OVX rat serum. Vicenin-2 was found to suppress the actions of ACP, E2, and BGP in OVX rats. Besides, Vicenin-2 showed some adverse effects over histomorphometric percentage and histological studies, in which tabular thickness and area were restored in the control and Vicenin-2 managed OVX rats. PCR results of Alp, Runx 2, Osx showed diminished expressions in OVX rats whereas treatment with Vicenin-2 displays up-regulated expression of these genes. Through our study, we established that Vicenin-2 did not wield a detrimental upshot on the skeletal organization of OVX rats. Besides, we put forward that Vicenin-2 could be an excellent candidate to treat and manage bone related disease or disorders.
El texto completo de este artículo está disponible en PDF.Keywords : Osteoporosis, Ovariectomy, Vicenin-2, Histomorphometry, Femur, Wistar rats
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Vol 129
Artículo 110474- septembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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