Marine compounds targeting the PI3K/Akt signaling pathway in cancer therapy - 28/08/20
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Graphical abstract |
The PI3K/Akt signaling pathway plays an important role in the development of cancer and is considered a therapeutic target of many cancer therapies. Bioactive marine compounds or their derivatives have antitumor effects by targeting PI3K/Akt signaling pathways by affecting protein synthesis, cell proliferation, angiogenesis, DNA repair, cell cycle, cell survival and so on. These marine compounds may have great potential to be developed into anticancer drugs.
Highlights |
• | First review of marine compounds that targeting PI3K/Akt signaling pathway in cancer therapy. |
• | Collection of marine compounds with unknown targets for future research on their molecular mechanisms. |
• | Innovative graphical exhibition of marine compounds with their regulated proteins and targeted cancers. |
Abstract |
Cancer is a disease characterized by overproliferation, including that due to transformation, apoptosis disorders, proliferation, invasion, angiogenesis and metastasis, and is one of the deadliest diseases. Currently, conservative chemotherapy is used for cancer treatment due to a lack of effective drugs. The PI3K/Akt signaling pathway plays a very essential role in the pathogenesis of many cancers, and abnormal activation of this pathway leads to abnormal expression of a series of downstream proteins, which ultimately results in the excessive proliferation of cancer cells. Therefore, the PI3K/Akt signaling pathway is a critical target in cancer treatment. Marine drugs have attracted much attention in recent years, and studies have found that many extracts from oceanic animals, plants and microorganisms or their metabolites exert antitumor effects, including antiproliferative effects or the induction of cell cycle arrest, apoptosis or autophagy. However, most anticancer targets and the mechanisms of marine compounds remain unclear. The great potential of the development of marine drugs provides a new direction for cancer treatment. This review focuses on marine compounds that target the PI3K/Akt signaling pathway for the prevention and treatment of cancer and provides comprehensive information for those interested in research on marine drugs.
El texto completo de este artículo está disponible en PDF.Abbreviations : ADR-resistant, AKR1C1, Akt or PKB, BCRP, CDC2, Cdc25C, CDK1/4/6, CML, CSCs, Cyt C, EC50, ERK, FAK, FLIP, FoxO1/O3a, GI50, GSK3β, HCC, HDAC, HK, HIF-1α, IC50, IGF-1R, IRS1, JNK, MAPK, MEK, MMP, MMP-2/-9, MNPs, mTOR, NMR, NFPA, Nrf2, NSCLC, PARP, PDK1, PI3K, PTEN, p70S6K, Rb, RCC, ROS, RyR, S6RP, Stat3/5, TIMP, TNBC, TNPs, VEGF, DA, Bos, WA, (19Z)-HCA, Stel B, acetyl RT, Exc. B, 4-CF, Thi, C800, C828, BBA, Het, Xyl B, HQ, Sin, Fuc, DC, AAP-H, Mer, EC
Keywords : PI3K/Akt, Marine compounds, Anticancer
Esquema
Vol 129
Artículo 110484- septembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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