Can FDG-PET/MR help to overcome limitations of sequential MRI and PET-FDG for differential diagnosis between recurrence/progression and radionecrosis of high-grade gliomas? - 31/08/20

Doi : 10.1016/j.neurad.2020.08.003

N. Pyatigorskaya ^a,^b,⁎ , B. Sgard ^c, M. Bertaux ^c, L. Yahia-Cherif ^b, A. Kas ^c,^d
^a Sorbonne Université, Assistance Publique Hôpitaux de Paris, Neuroradiology Department, Pitié-Salpêtrière -Charles Foix Hospital, Paris, France
^b Sorbonne Université, Univ Paris 6, UMR S 1127, CNRS UMR 722, Institut du Cerveau et de la Moelle épinière, F-75013 Paris, France
^c Assistance Publique Hôpitaux de Paris, Nuclear Medicine Department, Pitié Salpêtrière-Charles Foix Hospital, AP-HP, 47-83 Boulevard de l’Hôpital, 75651 Paris CEDEX 13, France
^d Sorbonne University, Laboratoire d’Imagerie Biomédicale, INSERM U1146, Paris, France

^⁎Corresponding author at: Service de Neuroradiologie, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75651 PARIS Cedex 13, France.Service de NeuroradiologieHôpital Pitié-Salpêtrière47-83 Boulevard de l'Hôpital75651 PARIS Cedex 13France

En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Monday 31 August 2020
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ABSTRACT

The aim of our study was assessing the potential of FDG-PET-MRI to overcome limitations of separately performed MRI and PET-FDG and improving the performance of high-grade gliomas evaluation. Combined PET-MRI analysis allowed differentiating between recurrence/progression and radionecrosis with improved diagnostic accuracy (95% vs 63% for PET and 82% for MRI). FDG being a reliable, cost-saving tracer in this indication, combined FDG PET-MRI analysis could play a significant role in the follow-up of high-grade brain tumors.

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Abbreviations : pCASL, DC, ROC, SUV

Keywords : PET-MRI, FDG, ASL, glioblastoma