Leukoaraiosis and earlier neurological outcome after mechanical thrombectomy in acute ischemic stroke - 16/10/20
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Graphical abstract |
Highlights |
• | Severe leukoaraiosis was inversely associated with ENI after MT. |
• | Severe leukoaraiosis was not associated with END after MT. |
• | Severe leukoaraiosis was associated with END in patients without sICH after MT. |
Abstract |
Background and purpose |
The aim of the study was to evaluate whether leukoaraiosis (LA) severity is associated with earlier neurological outcome in acute stroke patients undergoing mechanical thrombectomy.
Materials and methods |
In this retrospective multicenter study, we evaluated 273 acute stroke patients treated with mechanical thrombectomy. LA severity was graded as 0–2 (absent-to-moderate) versus 3–4 (severe) according to the van Swieten scale. The main clinical outcome was the proportion of early neurological improvement and early neurological deterioration. Early neurological improvement was defined as a decrease of≥4 points on the NIHSS, or an NIHSS score of zero 24hours after baseline assessment. Early neurological deterioration was defined as an increase of≥4 points on the NIHSS 24hours after baseline assessment.
Results |
There was a significantly lower early neurological improvement rate (17.1% versus 39.2%; P=0.006) and non-significantly higher early neurological deterioration rate (29.3% versus 17.7%; P=0.084) in patients with severe LA (sLA) compared with patients with absent-to-moderate LA. In multivariable analysis, sLA was inversely associated with early neurological improvement (OR, 0.31; 95% CI, 0.13–0.78; P=0.012). There was no significant association of sLA with early neurological deterioration. However, in patients without symptomatic intracranial hemorrhage, sLA was an independent predictor of early neurological deterioration (OR, 2.65; 95% CI, 1.09–6.45; P=0.032).
Conclusions |
sLA is a significant negative predictor of early neurological improvement and is an independent predictor of early neurological deterioration in patients without symptomatic intracranial hemorrhage.
El texto completo de este artículo está disponible en PDF.Keywords : Stroke, Thrombectomy, Leukoaraiosis, Earlier neurological outcome
Abbreviations : ASPECTS, END, ENI, LA, mTICI, NIHSS, OTR, SBP, sICH, sLA
Esquema
Vol 47 - N° 6
P. 428-432 - novembre 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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