Serum and ascitic fluid interleukin-17 in spontaneous bacterial peritonitis in Egyptian patients with HCV-related liver cirrhosis - 17/10/20
, Ahmed Ali Mohammed a, Aliaa Monir Higazi b, Esraa Abdel Magid Mahmoud a, Zienab Mostafa Saad cBienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
| páginas | 7 |
| Iconografías | 4 |
| Vídeos | 0 |
| Otros | 0 |
Abstract |
Background |
Spontaneous bacterial peritonitis (SBP) is a potentially lethal complication of ascites. The inflammatory response is very intense in case of SBP despite low concentration of bacteria in the ascitic fluid with IL-17A overproduced by intestinal Paneth cells and may have role in host immune defense and inflammatory response.
Aims |
To study the diagnostic performance of serum and ascitic fluid IL-17A as a marker of SBP and its correlation with renal function.
Methods |
120 cirrhotic patients including 80 patients with HCV-induced cirrhotic ascites but not with SBP and 40 patients with HCV-induced cirrhotic ascites with SBP were recruited. Serum and ascitic fluid IL17A were measured before and after treatment.
Results |
The mean serum and ascitic fluid levels of IL-17 in cirrhotic patients with SBP were significantly higher than in patients with cirrhosis without SBP (p < 0.001). Also, we found significant decline in both serum and ascitic fluid IL17 levels with successful treatment of SBP (p < 0.001). The sensitivity and specificity of serum IL17 was 100 % when using 92 pg/mL as cutoff. Meanwhile, sensitivity and specificity of ascitic fluid IL-17were 100 % when using 132 pg/mL as cutoff.
Conclusions |
IL-17 could be used as a possible diagnostic biomarker for SBP especially in culture negative and non-neutrocytic SBP and in monitoring therapeutic response. Also, it was shown to be related to hepatic and renal functions deterioration.
El texto completo de este artículo está disponible en PDF.Keywords : Liver cirrhosis, HCV, Spontaneous bacterial peritonitis, Interleukin-17, Acute kidney injury
Esquema
Vol 68 - N° 4
P. 237-243 - novembre 2020 Regresar al número
Artículo precedente
- A common glomerular transcriptomic signature distinguishes diabetic kidney disease from other kidney diseases in humans and mice
- Moustafa Abdalla, Mohamed Abdalla, Ferhan S. Siddiqi, Laurette Geldenhuys, Sri N. Batchu, Monica F. Tolosa, Darren A. Yuen, Claudia C. dos Santos, Andrew Advani
- Machine learning and artificial intelligence in the service of medicine: Necessity or potentiality?
- Tamim Alsuliman, Dania Humaidan, Layth Sliman
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?