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Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease : Running title: Propolis against SARS-CoV-2 infection and COVID-19 - 28/10/20

Doi : 10.1016/j.biopha.2020.110622 
Andresa Aparecida Berretta a , Marcelo Augusto Duarte Silveira b , José Manuel Cóndor Capcha c , David De Jong d,
a Research, Development and Innovation Department, Apis Flora Indl. Coml. Ltda, Ribeirão Preto, São Paulo, Brazil 
b D'Or Institute for Research and Education (IDOR), Hospital São Rafael, Salvador, Brazil 
c Interdisciplinary Stem Cell Institute at Miller School of Medicine, University of Miami, Miami, Florida, United States 
d Genetics Department, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil 

Corresponding author.

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Graphical abstract




El texto completo de este artículo está disponible en PDF.

Highlights

Propolis, made by bees from bioactive plant resins, has antiviral activity.
Propolis potentially can interfere with host cell invasion by SARS-CoV-2.
Propolis blocks proinflammatory PAK1, a kinase highly expressed in COVID19 patients.
Standardized propolis has consistent properties for lab and clinical research.
Propolis is a safe widely consumed functional food with medicinal properties.

El texto completo de este artículo está disponible en PDF.

Abstract

Propolis, a resinous material produced by honey bees from plant exudates, has long been used in traditional herbal medicine and is widely consumed as a health aid and immune system booster. The COVID-19 pandemic has renewed interest in propolis products worldwide; fortunately, various aspects of the SARS-CoV-2 infection mechanism are potential targets for propolis compounds. SARS-CoV-2 entry into host cells is characterized by viral spike protein interaction with cellular angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2. This mechanism involves PAK1 overexpression, which is a kinase that mediates coronavirus-induced lung inflammation, fibrosis, and immune system suppression. Propolis components have inhibitory effects on the ACE2, TMPRSS2 and PAK1 signaling pathways; in addition, antiviral activity has been proven in vitro and in vivo. In pre-clinical studies, propolis promoted immunoregulation of pro-inflammatory cytokines, including reduction in IL-6, IL-1 beta and TNF-α. This immunoregulation involves monocytes and macrophages, as well as Jak2/STAT3, NF-kB, and inflammasome pathways, reducing the risk of cytokine storm syndrome, a major mortality factor in advanced COVID-19 disease. Propolis has also shown promise as an aid in the treatment of various of the comorbidities that are particularly dangerous in COVID-19 patients, including respiratory diseases, hypertension, diabetes, and cancer. Standardized propolis products with consistent bioactive properties are now available. Given the current emergency caused by the COVID-19 pandemic and limited therapeutic options, propolis is presented as a promising and relevant therapeutic option that is safe, easy to administrate orally and is readily available as a natural supplement and functional food.

El texto completo de este artículo está disponible en PDF.

Keywords : Propolis, SARS-CoV-2, COVID-19, Antiviral, Anti-inflammatory, PAK1 blocker


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© 2020  The Author(s). Publicado por Elsevier Masson SAS. Todos los derechos reservados.
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Vol 131

Artículo 110622- novembre 2020 Regresar al número
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