Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents - 28/10/20
, Zhi-bin Wang c, ⁎ Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Graphical abstract |
Highlights |
• | Entecavir and imipenem alleviated LPS-induced cytokine storm syndrome. |
• | Entecavir and imipenem mitigated LPS-induced acute lung injury. |
• | Entecavir and imipenem inhibited LPS-stimulated TNF-α and IL-10 in hPBMC. |
• | Entecavir and imipenem attenuated LPS-activated NF-κB. |
Abstract |
Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has been widely spread in the world with a high mortality. Cytokine storm syndrome (CSS) and acute lung injury caused by SARS-CoV-2 infection severely threaten the patients. With the purpose to find effective and low-toxic drugs to mitigate CSS, entecavir and imipenem were identified to reduce TNF-α using a LPS-induced macrophage model from the anti-infective drug library. Entecavir and imipenem efficiently suppressed the release of inflammatory cytokines by partly intervention of NF-κB activity. The acute lung injury was also alleviated and the survival time was prolonged in mice. In addition, entecavir and imipenem inhibited the release of TNF-α and IL-10 in human peripheral blood mononuclear cells (hPBMCs). Collectively, we proposed that entecavir and imipenem might be candidates for the treatment of CSS.
El texto completo de este artículo está disponible en PDF.Abbreviations : ARDS, BALF, CCL-5, COVID-19, CSS, CXCL1, FDA, G-CSF, hPBMC, IC50, IL, IP10, LPS, MCP-1, MERS, MIP-1α, NLRP3, SARS-CoV-2
Chemical compounds studied in this article : Entercavir: PubChem CID 135398508, Imipenem: PubChem CID 104838
Keywords : Cytokine storm, COVID-19, Entecavir, Imipenem, Drug repurposing, Anti-inflammation
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Vol 131
Artículo 110643- novembre 2020 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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