CHI3L1 in the pathophysiology and diagnosis of liver diseases - 28/10/20

Doi : 10.1016/j.biopha.2020.110680

Shuwei Wang ^a,^e, Mengyuan Hu ^e, Yunsong Qian ^a,^e, Zhenluo Jiang ^a,^e, Lili Shen ^a,^e, Liyun Fu ^a,^b,^c,^d,⁎ , Yaoren Hu ^a,^b,^c,^d,⁎
^a Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China
^b Ningbo Institute of Life and Health Industry, University of Chinese Academy of Science, Ningbo 315010, China
^c Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo 315010, China
^d Ningbo Clinical Research Center for Digestive System Tumors (Grant No.2019A21003), Ningbo 315010, China
^e Medical School of Ningbo University, Ningbo 315211, China

^⁎Corresponding author at: Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.Department of HepatologyHwaMei HospitalUniversity of Chinese Academy of SciencesNingbo315010China

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Graphical abstract

Associated signal pathways of CHI3L1.

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Abstract

Chitinase 3-like protein 1(CHI3L1) participates in physiological and pathophysiological process, such as cell survival, cell proliferation, tissue remodeling, angiogenesis, etc. Some studies demonstrated that CHI3L1 is liver-enriched and has better application value in staging liver fibrosis than platelet ratio index(APRI) and ﬁbrosis-4 index(FIB-4) and that CHI3L1 can be used in monitoring the prognosis of hepatocellular carcinoma (HCC). In this review, we summarized the pathophysiological role and the diagnostic value of CHI3L1 in liver fibrosis in different background and HCC.

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Abbreviations : CHI3L1, CLP, IL, TNF, CEBPα, ICU, IL-13Rα2, MAPK, ERK, PI3K, AKT, SP, EMT, CAC, RAGE, SAPKs, JNK, MMP1, HS, FAK, VEGFR, Fibroscan, SWE, APRI, FIB-4, HBV, AUCs, CIV, PCIII, CHC, LT, ESLD, NAFL, T2D, ALD, HCC, RT-PCR, TNM, OS, DFS, AFP, BCLC, RFS, CLU, mAY, Flk-1/KDR

Keywords : CHI3L1, Liver fibrosis, Hepatocellular carcinoma, Biomarker, Mechanism

Esquema

Introduction

The functions of CHI3L1

The diagnostic power of CHI3L1 in liver fibrosis

The expression feature and prognostic power of CHI3L1 in HCC

Underling pathophysiological roles of CHI3L1 in liver fibrosis and HCC

Conclusion

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CHI3L1 in the pathophysiology and diagnosis of liver diseases - 28/10/20

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