Long non-coding RNA BLACAT1, a novel promising biomarker and regulator of human cancers - 18/11/20
, Shutian Zhang ⁎ Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
| páginas | 8 |
| Iconografías | 4 |
| Vídeos | 0 |
| Otros | 0 |
Graphical abstract |
Highlights |
• | Upregulated BLACAT1 plays an oncogenic role in most types of cancer. |
• | BLACAT1 manipulate multiple downstream targets via sponging to various miRNAs. |
• | BLACAT1 recruits PRC2, thus inhibiting gene expression at the epigenetic level. |
• | BLACAT1 is a candidate for molecular diagnosis and treatment in cancers. |
Abstract |
Emerging evidence has shown that aberrantly expressed long noncoding RNAs (lncRNAs) play a vital role in various biological processes of tumorigenesis. Bladder cancer associated transcript 1 (BLACAT1) is a novel lncRNA located on chromosome 1q32.1, which regulated multiple downstream targets via serving as a “sponge” for their corresponding microRNAs or by directly interacting with various regulating proteins. In this review, we summarized the role of BLACAT1 in the development and progression of different cancers. We also highlighted that BLACAT1 could be utilized as a potential biomarker and therapeutic target for human cancers.
El texto completo de este artículo está disponible en PDF.Abbreviations : lncRNAs, miRNA, siRNAs, EMT, TCGA, STAD, COAD, READ, PAAD, CESC, OV, UCEC, UCS, qRT-PCR, HCC, LUAD, BRCA, PRAD, ESCA, THCA, BLCA, NPC, ROC, AUC, LNM, OS, DFS, MFS, RIP, ChIP, KIRC, LGG, CSCC, NSCLC, SCLC, ESCC, CRC, HNCs, OSCC, HNSCC, PTC, EZH2, SUZ12, PRC2, CCND2, SERPINB2, BMP2, HOXA5, CCR2, TAM, DNMT1, HDAC1, MDM2, MAPK, STAT3, ATG7, MRP1, LRP1, ABCB1, IC50, VASP, AML
Keywords : Long non-coding RNA, BLACAT1, Biomarker, Cancer
Esquema
Vol 132
Artículo 110808- décembre 2020 Regresar al número
Artículo precedente
- Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19
- Jayanta Talukdar, Bhaskar Bhadra, Tomal Dattaroy, Vinod Nagle, Santanu Dasgupta
- Aptamers used for biosensors and targeted therapy
- Yi Ning, Jue Hu, Fangguo Lu
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?