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From the perspective of Traditional Chinese Medicine: Treatment of mental disorders in COVID-19 survivors - 18/11/20

Doi : 10.1016/j.biopha.2020.110810 
Ke Ma a, , 1 , Xin Wang a, 1, Shiyao Feng a, 1, Xueshan Xia b, Hongxiu Zhang c, Abdul Rahaman d, Zhenfei Dong a, Yanting Lu a, Xiuyang Li a, Xiaoyu Zhou a, Haijun Zhao a, Yuan Wang a, Shijun Wang a, Zulqarnain Baloch b,
a College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China 
b Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China 
c Institute of Virology, Jinan Municipal Center for Disease Control and Prevention, Jinan, 250021, China 
d School of Food Science and Engineering, South China University and Technology, Guangzhou, China 

Corresponding author at: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China.Faculty of Life Science and TechnologyKunming University of Science and TechnologyKunmingYunnan650500China⁎⁎Corresponding author at: Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, No. 4655, University Road, Changqing District, Jinan, Shandong, 250355, China.Shandong Co-Innovation Center of Classic TCM FormulaShandong University of Traditional Chinese MedicineNo. 4655University RoadChangqing DistrictJinanShandong250355China

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Highlights

Mental disorders in COVID-19 patients and survivors revealed that the COVID-19 had immune dysfunction.
Analysing the symptoms of COVID-19, TCM syndrome of the depression, anxiety and PTSD was interpreted as internal heat and Yin deficiency.
Depression, anxiety and PTSD pertains the category of “lily disease”, “hysteria” and “deficient dysphoria” in TCM.
Lily Bulb and Rehmannia Decoction, Lily Bulb and Anemarrhenae Decoction and Ganmai Dazao Decoction were used to treat the depression.

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Abstract

Purpose

The aim of this study is to explore the possible benefits of traditional Chinese medicine on the pathogenesis of psychological and mental health of COVID-19 survivors.

Methods

A literature search was conducted to confirm the effects of COVID-19 on psychological and mental health of survivors. In addition to this, on the basis of signs and symptoms, TCM were used on treat mental disorder as per suggested clinical and animal experimental data plus relevant records in classical Chinese medicine books written by Zhang Zhongiing during Han Dynasty. A series of treatment plans were prescribed for COVID-19 survivors with psychological and mental disorders.

Results

According to previous extensive studies focusing on effects on mental health of survivors, high incidence was observed in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) survivors. During investigations of mental health of COVID-19 patients and survivors, it is observed that they also had symptoms of mental disorders and immune dysfunction. Furthermore, it was also proposed that depression, anxiety and post-traumatic stress disorder (PTSD) were most common mental disorders requiring special attention after the recovery from COVID-19. The symptoms of COVID-19 were analyzed, and the TCM syndrome of the depression, anxiety and PTSD after recovered from COVID19 was interpreted as internal heat and Yin deficiency. These three mental disorders pertains the category of “Lily disease”, “hysteria” and “deficient dysphoria” in TCM.

Conclusion

Lily Bulb, Rhizoma Anemarrhena Decoction and Ganmai Dazao Decoction were used to treat depression. Suanzaoren Decoction, Huanglian Ejiao Decoction and Zhizi Chi Decoction were suggested for anxiety. Moreover, Lily Bulb, Rehmannia Decoction and Guilu Erxian Decoction were the formula for PTSD.

El texto completo de este artículo está disponible en PDF.

Abbreviations : TCM, COVID-19, SARS, MERS, PTSD, PHEIC, IL-1β, IL-6, IL-8, IL-10, TNF-α, NE, 5-HT, DA, FST, TST

Keywords : COVID-19, Depression, Anxiety, Post-traumatic stress disorder, Traditional Chinese medicine


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© 2020  The Authors. Publicado por Elsevier Masson SAS. Todos los derechos reservados.
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Vol 132

Artículo 110810- décembre 2020 Regresar al número
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