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Compliance with antibiotic prophylaxis guidelines in surgery: Results of a targeted audit in a large-scale region-based French hospital network - 26/11/20

Doi : 10.1016/j.medmal.2020.10.005 
N. Prévost a, A. Gaultier b, G. Birgand c, J. Mocquard a, N. Terrien b, E. Rochais a, , R. Dumont d
a Observatoire du médicament, des dispositifs médicaux et de l’innovation thérapeutique (OMEDIT) Pays de la Loire, 85, rue Saint-Jacques, 44093 Nantes, France 
b Réseau Qualirel santé, 85, rue Saint-Jacques, 44093 Nantes, France 
c CPias Pays de la Loire, CHU de Nantes, 5, rue Professeur Yves-Boquien, 44093 Nantes, France 
d CHU de Nantes, 5, allée de l’Île Gloriette, 44093 Nantes, France 

Corresponding author.
En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Thursday 26 November 2020
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Highlights

Twenty-six healthcare facilities (67% of the facilities in the region) volunteered to participate in the audit.
2303 files were evaluated.
Overall compliance with ABP guidelines was found in only 64% of the files evaluated, a result similar to the literature and to a 2008 study.
Injection timing (0–60 minutes before incision) is the most problematic indicator, as compliance was shown in only 77.6% of the files.
Elaboration of a regionwide action plan.

El texto completo de este artículo está disponible en PDF.

Abstract

Introduction

While regional monitoring of antibiotic use has decreased since 2011 by 3.2%, in some healthcare facilities a significant increase (+43%) has occurred. The purpose of this study was to assess regional antibiotic prophylaxis (ABP) compliance with national guidelines.

Material and methods

In 2015, 26 healthcare facilities, both public and private, were requested to audit five items: utilization of antibiotic prophylaxis, the antimicrobial agent (the molecule) administered, time between injection and incision, initial dose, number of intraoperative and postoperative additional doses. Seven surgical procedures were selected for assessment: appendicectomy (APP), cataract (CAT), cesarean section (CES), colorectal cancer surgery (CCR), hysterectomy (HYS), total hip arthroplasty (THA) and transurethral resection of the prostate (TURP). A statistical analysis of the 2303 records included was carried out.

Results

The general rate of antibiotic prophylaxis compliance was 64%. The antimicrobial agent used and initial dose were in compliance with the guidelines for 93% and 97.4% of cases respectively, and administration of antibiotic prophylaxis was achieved 60minutes before incision in 77.6% of the records included. Regarding gastrointestinal surgery, amoxicillin/clavulanic acid was used in 32% of patients. In 26% of appendectomy files, administration occurred after incision, and one out of two files showed non-complaint perioperative and postoperative consumption.

Conclusion

Compliance with nationwide ABP guidelines is in need of pronounced improvement, especially with regard to time interval between injection and incision and the molecule prescribed. An action plan based on specific recommendations addressed to each establishment and an updated regionwide ABP protocol are aimed at achieving better and reduced consumption of antimicrobial agents.

El texto completo de este artículo está disponible en PDF.

Keywords : Antibiotic prophylaxis/statistics & numerical data, Clinical audit, Guideline adherence, Surgical Wound/Surgical site Infection/prevention & control*


Esquema


 Presentation in congresses: where do we stand with regard to surgical antibiotic prophylaxis (ABP)? Results of a regionwide study. Nicolas Prévosta, Aurélie Gaultierb, Julie Mocquarda, Cécile Loonisb, Gabriel Birgandc, Aurélie Marqueta, Jean-Claude Maupetita, Romain Dumontd. aOMEDIT Pays de la Loire; bRéseau Qualisanté; cAntenne régionale de lutte contre les infections nosocomiales (ARLIN) Pays de la Loire; dCHU de Nantes; congrès de la SFAR, septembre 2016, Paris, France. Évaluation régionale des pratiques d’antibioprophylaxie (ABP) chirurgicale/Regionwide evaluation of current practices in surgical antibiotic prophylaxis (ABP). F. d’Acremonta, J. Mocquarda, N. Prévosta, A. Marquetb, E. Batardb, E. Rochaisa, J-C. Maupetita. aUnité de coordination régionale, OMEDIT Pays de la Loire; bObservatoire des antibiotiques, OMEDIT Pays de la Loire; congrès Hopipharm, mai 2017, Nancy, France.


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