EMT, cancer stem cells and autophagy; The three main axes of metastasis - 19/12/20
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Graphical abstract |
Highlights |
• | EMT, cancer stem cells and autophagy are the three main axes of cancer cell metastasis. |
• | EMT and cancer stem cells are closely related to each other, play a key role in metastasis. |
• | Crosslink between autophagy and EMT can open a novel scenario for molecular mechanism of metastasis. |
• | Autophagy plays a dual role in cancer stem cells and metastasis. |
Abstract |
Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways involved in both processes are appropriate therapeutic targets in the treatment of metastasis. Autophagy is another process that has recently attracted the attention of many researchers; depending on the type of cancer and tissue and the stage of cancer, this process can play a dual role in the development of cancer cells. Studies on cancer cells have shown that different signaling pathways are involved in all three processes, namely, cancer stem cells, autophagy, and EMT. The purpose of this study was to investigate and elucidate the relationship between the effective signaling pathways in all three processes, which could play an effective role in determining appropriate therapeutic goals.
El texto completo de este artículo está disponible en PDF.Keywords : Metastasis, EMT, Cancer stem cells, Autophagy
Esquema
Vol 133
Artículo 110909- janvier 2021 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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