Wnt signaling: An attractive target for periodontitis treatment - 19/12/20
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Highlights |
• | The Wnt signaling plays an important role in periodontal biology. |
• | Activating the Wnt signaling can reconstruct periodontal tissues. |
• | Agents targeting the Wnt signaling may be an adjunct to periodontitis treatment. |
Graphical abstract |
Abstract |
Periodontitis is the most common chronic inflammatory disease, and a leading cause of tooth loss. Characterized by resorption of alveolar process and destruction of periodontal ligaments, periodontitis can impact not only periodontal tissues but also systemic diseases, such as diabetes, cardiovascular diseases, and respiratory infections. Currently, it is a hotspot to manage destruction and gain regeneration of periodontal tissues. Increasing evidence indicates that the Wnt signaling plays an important role in homeostasis of periodontal tissues, functions of periodontal derived cells, and progression of periodontitis. Its molecule expressions were abnormal in periodontitis. As such, modulators targeting the Wnt signaling may be an adjuvant therapy for periodontitis treatment. This review elucidates the role of Wnt signaling and its molecules, with a view to develop a potential application of drugs targeting the Wnt signaling for periodontitis treatment.
El texto completo de este artículo está disponible en PDF.Keywords : Wnt signaling pathway, Periodontitis, Alveolar process, Dental cementum, Periodontal ligament
Esquema
Vol 133
Artículo 110935- janvier 2021 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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