Effects of ω-3 PUFA and ascorbic acid combination on post-resuscitation myocardial function - 19/12/20
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Graphical abstract |
Highlights |
• | ω-3 PUFA and AA suppress lipid peroxidation; improve myocardial function. |
• | ω-3 PUFA or AA treatment improves outcomes in a rat model of cardiac arrest. |
• | A combination of ω-3 PUFA and AA therapy shows a synergy effect. |
• | ω-3 PUFA or AA is a potential new therapeutic during cardiopulmonary resuscitation. |
Abstract |
Accumulating evidence demonstrated that administration of ω-3 polyunsaturated fatty acid (ω-3 PUFA) or ascorbic acid (AA) following cardiac arrest (CA) improves survival. Therefore, we investigate the effects of ω-3 PUFA combined with AA on myocardial function after CA and cardiopulmonary resuscitation (CPR) in a rat model.
Thirty male rats were randomized into 5 groups: (1) sham; (2) control; (3) ω-3 PUFA; (4) AA; (5) ω-3 PUFA + AA. Ventricular fibrillation (VF) was induced and untreated for 6 min followed by defibrillation after 8 min of CPR. Infusion of drug or vehicle occurred at the start of CPR. Myocardial function and sublingual microcirculation were measured at baseline and after return of spontaneous circulation (ROSC). Heart tissues and blood were collected 6 h after ROSC. Myocardial function and sublingual microcirculation improvements were seen with ω-3 PUFA or AA compared to control after ROSC (p < 0.05). ω-3 PUFA + AA shows a better myocardial function than ω-3 PUFA or AA (p < 0.05). ω-3 PUFA or AA decreases pro-inflammatory cytokines, cTnI, myocardium malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) modified proteins compared to control (p < 0.05). ω-3 PUFA and AA combined have lower MDA and 4-HNE modified proteins than alone (p < 0.05). ω-3 PUFA or AA treatment reduces the severity of post-resuscitation myocardial dysfunction, improves sublingual microcirculation, decreases lipid peroxidation and systemic inflammation in the early phase of recovery following CA and resuscitation. A combination of ω-3 PUFA and AA treatment confers an additive effect in suppressing lipid peroxidation and improving myocardial function.
El texto completo de este artículo está disponible en PDF.Abbreviations : CO, EF, MFI, MPI, MDA, PVD, ROSC, SOD, 4-HNE
Keywords : ω-3 Polyunsaturated fatty acid, Ascorbic acid, Post-resuscitation, Myocardial function, Myocardial ischemia/reperfusion injury
Esquema
Vol 133
Artículo 110970- janvier 2021 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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