cGAS-STING signaling in cancer immunity and immunotherapy - 19/12/20
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Graphical abstract |
Highlights |
• | cGAS-STING pathway recognizes cytoplasmic DNA,inducing type I interferon response. |
• | Anti-tumor mechanisms of the cGAS-STING pathway are described. |
• | The preclinical and clinical applications of STING agonists are summarized. |
Abstract |
Recent studies have shown that the innate immune cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway may play an important role in antitumor immunity. Additionally, the cGAS-STING pathway promotes the senescence of cancer cells, induces apoptosis of cancer cells, and increases the protective effect of cytotoxic T cells and natural killer cell-mediated cytotoxicity. We believe that the combination of the cGAS-STING signaling pathway with other therapeutic methods provides a new perspective from which to overcome obstacles in the application of this review. Further, we highlight the antitumor mechanism of the cGAS-STING signaling pathway and the latest advances in monotherapy and combination therapy with related agonists.
El texto completo de este artículo está disponible en PDF.Abbreviations : CDN, CRMPC, DDR, DMBA, DMXAA, ER, ERGIC, HGSC, HNSCC, ICB, IDO, IFN, IFNAR, MTD, NK, NSCLC, OS, PD, PFS, PK, RT, SASP, SAVI, SCLC, STING, TCGA, TIS
Keywords : cGAS-STING signaling, Cancer immunity, Cancer therapy, Antitumor
Esquema
Vol 133
Artículo 110972- janvier 2021 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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