Regulatory role of microRNAs on PTEN signaling - 19/12/20

Doi : 10.1016/j.biopha.2020.110986

Soudeh Ghafouri-Fard ^a, Atefe Abak ^b, Hamed Shoorei ^c, Mahdi Mohaqiq ^d, Jamal Majidpoor ^e, Arezou Sayad ^a, Mohammad Taheri ^f,^g,⁎
^a Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
^b Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
^c Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
^d Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, USA
^e Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
^f Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
^g Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

^⁎Corresponding author at: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Urology and Nephrology Research CenterShahid Beheshti University of Medical SciencesTehranIran

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Abstract

Phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor protein which is altered in several malignancies. This protein is a negative regulator of the PI3K/AKT signaling. Several transcription factors regulate the expression of PTEN in positive or negative directions. Moreover, numerous microRNAs (miRNAs) have functional interactions with PTEN and inhibit its expression. Suppression of PTEN can attenuate the response of cancer cells to chemotherapeutic agents. Based on the critical role of this tumor suppressor gene, the identification of negative regulators of its expression has practical significance particularly in the prevention and management of cancer. Meanwhile, the interaction between miRNAs and PTEN has functional consequences in non-malignant disorders including myocardial infarction, osteoporosis, cerebral ischemic stroke, and recurrent abortion. In the present review, we describe the role of miRNAs in the regulation of expression and activity of PTEN.

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Abbreviations : PTEN, miRNAs, PI3Ks, TFs, APL, ATRA, 3’ UTR, EMT, AML, ESCC, KC, BC, MM, OS, NPC, EC, BCL, OC, HCC, PCa, CRC, LUAD, NSCLC, RCC, GC, WT, PaC, GBM, RB, ICC, AMI, MIR, MI, AKI, PAH, OP, AP, AS, DR, CHF, DVT, CIS, SAP, AD, RSA

Keywords : miRNA, PTEN, Cancer, Disorder

Esquema

Introduction

Interaction between miRNAs and PTEN in cancers

Interaction between miRNAs and PTEN in other disorders

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Conclusion

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Vol 133

Artículo 110986- janvier 2021 Regresar al número

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Regulatory role of microRNAs on PTEN signaling - 19/12/20

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