Association between chronic stress and Alzheimer’s disease: Therapeutic effects of Saffron - 19/12/20
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Highlights |
• | Two important landmarks of Alzheimer's disease (AD) are aggregation of Aβ into amyloid plaques and tau within brain tissue. |
• | Both Chronic stress and AD are associated with synaptic and neuronal loss and cognitive deficits. |
• | Chronic stress via increasing p-tau plays an important role in the development of AD. |
• | Saffron and its main constitute crocin have inhibitory effects on aggregation of Aβ into and tau proteins. |
• | Saffron and crocin might be a promising target for treatment of AD and stress-related disorders. |
Abstract |
Chronic stress and high levels of glucocorticoids produce functional and structural changes in brain and especially in the hippocampus, an important limbic system structure that plays a key role in cognitive functions including learning and memory. Alzheimer's disease (AD) is a chronic neurodegenerative disease that usually starts slowly and worsens over time. Indeed, cognitive dysfunction, neuronal atrophy, and synaptic loss are associated with both AD and chronic stress. Recent preclinical and clinical studies have highlighted a possible link between chronic stress, cognitive decline and the development of AD. It is suggested that Tau protein is an essential mediator of the neurodegenerative effects of stress and glucocorticoids towards the development of AD pathology. Recent findings from animal and humans studies demonstrated that saffron and its main constitutive crocin are effective against chronic stress-induced cognitive dysfunction and oxidative stress and slowed cognitive decline in AD. The inhibitory actions on acetylcholinesterase activity, aggregation of beta-amyloid protein into amyloid plaques and tau protein into neurofibrillary tangles, and also the antioxidant, anti-inflammatory, and the promotion of synaptic plasticity effects are among the possible mechanisms to explain the neuroprotective effects of saffron. New evidences demonstrate that saffron and its main component crocin might be a promising target for cognition improvement in AD and stress-related disorders.
El texto completo de este artículo está disponible en PDF.Abbreviations : AD, APP, Aβ, HPA, ACTH, GC, ROS, NMDA, LTP, SOD, GPx, GSH, MDA, TBARS, AChE
Keywords : Saffron, Chronic stress, Alzheimer’s disease, Cognitive dysfunction
Esquema
Vol 133
Artículo 110995- janvier 2021 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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