Médecine

Paramédical

Autres domaines


Suscribirse

COVID-19 in French patients with chronic inflammatory rheumatic diseases: Clinical features, risk factors and treatment adherence - 11/02/21

Doi : 10.1016/j.jbspin.2020.105095 
Félicie Costantino a, b, Léa Bahier b, Luis Coronel Tarancón b, Ariane Leboime b, François Vidal b, Lamouri Bessalah c, Maxime Breban a, b, Maria-Antonietta D’Agostino a, b,
a Inserm U1173, Infection et inflammation, Laboratory of Excellence INFLAMEX, Université Paris-Saclay, UVSQ, Montigny-Le-Bretonneux, France 
b Rheumatology Department, AP–HP, Ambroise Paré Hospital, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France 
c BEPATIENT, Paris, France 

Corresponding author at: Rheumatology Department, AP–HP, Ambroise Paré Hospital, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.Rheumatology Department, AP–HP, Ambroise Paré Hospital9, avenue Charles-de-GaulleBoulogne-Billancourt92100France

Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
Artículo gratuito.

Conéctese para beneficiarse!

Highlights

Incidence of COVID 19 was not increased in patients with inflammatory rheumatisms.
Continuation of anti-rheumatic drugs was not associated with an increased risk of COVID-19.
In inflammatory rheumatisms treatment adherence was reduced because of fear of contagion.

El texto completo de este artículo está disponible en PDF.

Abstract

Objective

To explore how patients with chronic inflammatory rheumatic diseases (CIRDs) coped with their disease during the COVID-19 pandemic and to identify possible predictive factors of SARS-CoV-2 infection in this population.

Methods

Patients followed in a single rheumatology department in France or registered on the Spondy+ platform, a secure e-health platform for spondyloarthritis patients, were invited to complete a questionnaire focused on their experiences around COVID19 symptoms, testing and medications access during the lockdown period. Descriptive statistics were used to report questionnaire's results. Factors associated with COVID-19 or with treatment discontinuation were assessed by logistic regression.

Results

We obtained 655 answers from the 2,081 contacted patients: 474 with spondyloarthritis, 129 with rheumatoid arthritis and 52 with psoriatic arthritis. The population was predominantly female (61.8%) with a mean age of 51.0±13.4 years. Incidence of COVID-19 was 6.9% (95%CI: 5.1–9.2%), including 12 confirmed and 33 highly suspicious cases. No death was observed and five patients needed to be hospitalized. Factors independently associated with an increased risk of infection were SARS-CoV-2 exposure, younger age and non-smoking. More than 30% of the patients suspended or decreased the dosage of one of their drugs during the lockdown period. This was followed in 63.4% of them by increased disease activity. Modifications were mostly motivated by fear of contagion (79.3%).

Conclusion

We did not observe any increase of incidence or severity of COVID-19 in patients suffering of the 3 most common CIRDs. This survey also adds evidence of the safety of anti-rheumatic drugs use regarding COVID-19.

El texto completo de este artículo está disponible en PDF.

Keywords : COVID-19, Spondyloarthritis, Psoriatic arthritis, Rheumatoid arthritis, Non-steroidal anti-inflammatory drugs


Esquema


© 2020  Société française de rhumatologie. Publicado por Elsevier Masson SAS. Todos los derechos reservados.
Añadir a mi biblioteca Eliminar de mi biblioteca Imprimir
Exportación

    Exportación citas

  • Fichero

  • Contenido

Vol 88 - N° 1

Artículo 105095- janvier 2021 Regresar al número
Artículo precedente Artículo precedente
  • Inadequacies of the Lasègue test, and how the Slump and Bowstring tests are useful for the diagnosis of sciatica
  • Jean-Marie Berthelot, Christelle Darrieutort-Laffite, Paul Arnolfo, Joëlle Glémarec, Benoît Le Goff, Yves Maugars
| Artículo siguiente Artículo siguiente
  • Attainment of the Patient-acceptable Symptom State in 548 patients with rheumatoid arthritis: Influence of demographic factors
  • Catia Duarte, Eduardo Santos, Tore Kristian Kvien, Maxime Dougados, Maarten de Wit, Laure Gossec, José António Pereira da Silva

Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.

Mi cuenta


Declaración CNIL

EM-CONSULTE.COM se declara a la CNIL, la declaración N º 1286925.

En virtud de la Ley N º 78-17 del 6 de enero de 1978, relativa a las computadoras, archivos y libertades, usted tiene el derecho de oposición (art.26 de la ley), el acceso (art.34 a 38 Ley), y correcta (artículo 36 de la ley) los datos que le conciernen. Por lo tanto, usted puede pedir que se corrija, complementado, clarificado, actualizado o suprimido información sobre usted que son inexactos, incompletos, engañosos, obsoletos o cuya recogida o de conservación o uso está prohibido.
La información personal sobre los visitantes de nuestro sitio, incluyendo su identidad, son confidenciales.
El jefe del sitio en el honor se compromete a respetar la confidencialidad de los requisitos legales aplicables en Francia y no de revelar dicha información a terceros.