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A German AWMF’s S2e/realist synthesis and meta-narrative snapshot of craniomaxillofacial manifestations in COVID-19 patients: Rapid living update on 1 January 2021 - 11/02/21

Doi : 10.1016/j.jormas.2021.01.012 
Poramate Pitak-Arnnop a, , Jean-Paul Meningaud b, Nattapong Sirintawat c, Keskanya Subbalekha d, Prim Auychai e, Anak Iamaroon f, g, Pornchai O-Charoenrat h, Surajit Suntorntham i, Robert Messer-Peti j, Andreas Neff a
a Department of Oral and Maxillofacial Surgery, University Hospital of Giessen and Marburg, UKGM GmbH, Campus Marburg, Faculty of Medicine, Philipps-University of Marburg, Marburg, Germany 
b Department of Plastic, Reconstructive, Aesthetic and Maxillofacial Surgery, Henri Mondor University Hospital, AP-HP, Faculty of Medicine, University Paris-Est Créteil Val de Marne (Paris XII), Créteil, France 
c Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand 
d Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand 
e Department of Paediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand 
f Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chaing Mai, Thailand 
g Excellence Center in Osteology Research and Training Center (ORTC), Chiang Mai University, Chaing Mai, Thailand 
h Centre of Head, Neck and Breast Surgery, MedPark Hospital, Bangkok, Thailand 
i HRH Princess Chulabhorn College of Medical Science, Chulaborn Royal Academy, Bangkok, Thailand 
j Department of Urology, Medius Klinik Ostfildern‐Ruit – Academic Teaching Hospital of University Tübingen, Ostfildern, Germany 

Corresponding author at: Klinik für MKG-Chirurgie, Universitätsklinikum Marburg, UKGM, Baldingerstr., 35043 Marburg, Germany.Klinik für MKG-ChirurgieUniversitätsklinikum MarburgUKGMBaldingerstr.Marburg35043Germany

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En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Thursday 11 February 2021

Abstract

Purposes

To execute a review answering the following question: “Among novel coronavirus disease (COVID19) patients, what are craniomaxillofacial (CMF) manifestations?” based on the RAMESES and the German Association of Scientific Medical Societies (AWMF)’s S2e guidelines.

Methods

We performed a realist synthesis and meta-narrative review extracting data in English, French, German and Thai from PubMed/Medline, Embase, Biomed Central, Cochrane Library, and Thai Journals Online, until 1 January 2021. The primary outcome variable was CMF manifestations grouped into 5 categories: (1) mouth and throat, (2) nose, paranasal sinus, and skull base (3) ocular/orbital and periorbital tissue, (4) ear, and (5) craniofacial skin. Appropriate statistics was computed.

Results

Thirty-seven original articles meeting the inclusion criteria were analysed; all were in English and indexed in PubMed/Medline. Hand searches of their references yielded a total of 101 articles for the review. Most data were in low level of evidence and focused on smell and taste disturbances and non-specific orofacial lesions. Iatrogenic complications may occur in this body region. Conservative measures remained effective and were usually enough for patient care.

Conclusion

Because SARS-CoV-2 infection is new and becomes the stringent worldwide pandemic within a short time period, most of the data on CMF symptoms are of low level evidence. Apart from taste and smell dysfunctions, non-specific CMF lesions can be found and treated conservatively. Treatment complications are possible. Dentists and CMF surgeons are privileged to examine the orofacial region and work closely with colleagues in other specialities to combat this pandemic.

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Keywords : COVID-19, Craniomaxillofacial region, Head and neck, Signs and symptoms, Review


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