Metformin decreased myocardial fibrosis and apoptosis in hyperhomocysteinemia -induced cardiac hypertrophy - 12/02/21
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
| páginas | 7 |
| Iconografías | 4 |
| Vídeos | 0 |
| Otros | 0 |
Highlights |
• | Metformin attenuated homocysteine-induced cardiac hypertrophy. |
• | Metformin decreased myocardial fibrosis in homocysteine-induced cardiac hypertrophy. |
• | Metformin attenuated homocysteine-induced apoptosis in vivo and in vitro. |
Abstract |
Background |
Hyperhomocysteinemia (HHcy) is one of the major risk factors of cardiovascular diseases. Metformin acts as a cardioprotective role in several cardiovascular diseases, including ischemia/reperfusion, atherosclerosis, and myocardial infarction. However, whether metformin protects against HHcy-induced cardiac hypertrophy is unclear.
Methods and Results |
HHcy model was established in C57BL/6 mice with high L-methionine (L-MET) diet for 12 weeks. AC16 cells were exposed to homocysteine (Hcy) and then intervened with different concentrations of metformin in in vitro studies. The results showed that HHcy was able to induce cardiac hypertrophy, and metformin could abrogate this effect. HHcy increased the fibrosis area and induced apoptosis in the myocardium, whereas metformin could reverse the detrimental effects above. TUNEL assay showed that metformin was able to decrease Hcy-induced apoptosis in AC16 cells. Moreover, western blotting assay revealed that metformin could decrease Hcy-induced expression of Bax and cleaved caspase3, and increase the expression of Bcl-2.
Conclusions |
This study demonstrates that metformin is able to attenuate HHcy-induced cardiac hypertrophy by decreasing myocardial fibrosis and apoptosis.
El texto completo de este artículo está disponible en PDF.Abbreviations : HHcy, HW/BW, WGA, ANP, TUNEL, Bcl-2, BAX, AMPK, H&E, LVESD, LVEDD, LVEF, FS, L-methionine
Keywords : Homocysteine, Cardiac hypertrophy, Metformin, Apoptosis, Myocardial fibrosis
Esquema
Vol 69 - N° 1
Artículo 103270- janvier 2021 Regresar al número
Artículo precedente
- Does Ibrutinib impact outcomes of viral infection by SARS-CoV-2 in mantle cell lymphoma patients?
- Tamim Alsuliman, Sylvia Faict, Florent Malard, Alexis Genthon, Eolia Brissot, Zoé Van de Wyngaert, Souhila Ikhlef, Anne Banet, Simona Lapusan, Simona Sestili, Elise Corre, Fella M’hammedi-Bouzina, Louis Schaeffer, Ollivier Legrand, Rémy Dulery, Mohamad Mohty, Zora Marjanovic
- Selective dysregulation of ABC transporters in methotrexate-resistant leukemia T-cells can confer cross-resistance to cytarabine, vincristine and dexamethasone, but not doxorubicin
- Narges Aberuyi, Soheila Rahgozar, Elnaz Pourabutaleb, Kamran Ghaedi
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?