An integrative strategy for discovery of functional compound combination from Traditional Chinese Medicine: Danhong Injection as a model - 16/04/21
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Abstract |
Traditional Chinese Medicine formulas, which are usually considered exerting their holistic clinical benefits via multi-component, multi-target manner, are unique resources for the discovery of multi-component drug combinations. In order to screen and optimize the functional compound combination (FCC) from TCM, we established a novel four-step ‘GCIC’ strategy, including ‘Global profiling’, ‘Chemical structural classification’, ‘Intra-group screening’ and ‘Component-knockout optimization’. Following this strategy, an FCC consisted of four components from Danhong Injection (DHI) was identified, containing ferulic acid, cryptotanshinone, quercetin and anhydrosafflor yellow B. The holistic neuroprotective effects of the FCC were further investigated, indicating that the combination can both activate the antioxidative and anti-inflammatory responses in PC12 cells to protect them from oxidative stress. Major signaling pathways as Nrf2/ARE and Nrf2/AMPK/GSK3β were involved in the protective process of FCC. The ‘GCIC’ strategy established in this study might provide an alternation to traditional strategies in discovering the bioactive components from herbal medicines, especially compounded TCM formulas.
El texto completo de este artículo está disponible en PDF.Graphical Abstract |
Highlights |
• | ‘GCIC’ strategy was establish for drug discovery from TCM. |
• | An FCC consisted of 4 components from Danhong Injection was discovered. |
• | The FCC exerted its neuroprotection via antioxidative and anti-inflammatory routes. |
Keywords : Functional compound combination, Danhong Injection, Traditional Chinese Medicine, Oxidative stress, Inflammation
Esquema
Vol 138
Artículo 111451- juin 2021 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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